CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10311
Family Name Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3-chlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone family
No. of Seeds 20 No. of Other Members 13
Family Centroid CFAMM00401202 Functional Category Bioactive
Superfamily Lysosomal Pro-X carboxypeptidase Binder Superfamily 3
Class Class 213

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Cannabinoid receptor 1 Ligand Rimonabant Family 20 260
Cannabinoid receptor 1 Ligand TM38837 Family 20 15
Kinase and DNAPKi Inhibitor CC-115 Family 1 1
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 7 19
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
P2X purinoceptor 7 inhibitor N-[(2-chloro-3,4-difluorophenyl)m... 6 64
P2X purinoceptor 7 inhibitor N-[[2-chloro-3-(trifluoromethyl)p... 3 10
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 16
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 2 19
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Cannabinoid receptor 1 ligand SureCN4819820 family 11 5
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 4 15
Lysosomal Pro-X carboxypeptidase inhibitor [4-[2-(3-chloro-4-f... 5 0
Lysosomal Pro-X carboxypeptidase inhibitor [(1R,2R,4S)-4-amino... 9 0
Coagulation factor X inhibitor SureCN8169809 family 12 18
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
Cannabinoid receptor 1 ligand AGN-PC-07R5TU family 11 0
Cannabinoid receptor 1 ligand AGN-PC-07NHI2 family 4 1
Cannabinoid receptor 1 ligand AGN-PC-07RA3R family 15 0
Cannabinoid receptor 1 ligand SureCN3822127 family 5 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QS family 5 0
Dipeptidyl peptidase 4 inhibitor (3R)-3-amino-1-(3-methyl-6,7-... 6 1
Dipeptidyl peptidase 4 inhibitor (3R)-3-amino-1-[3-(4-chloroph... 2 0
P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401228 CHEMBL2023202 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(2,5-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401208 CHEMBL2022793 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3,4-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401234 CHEMBL2022787 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3-chloro-4-methylphenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401227 CHEMBL2023208 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chloro-3-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401214 CHEMBL2024197 Bioactive [4-[2-(3-chloro-4-fluorophenyl)pyrazol-3-yl]piperidin-1-yl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone
CFAMM00401233 CHEMBL2023211 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(5-chloro-2-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401213 CHEMBL2024196 Bioactive [4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone
CFAMM00401226 CHEMBL2023209 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401206 CHEMBL2022794 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(2,4-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401232 CHEMBL2023212 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(2-chloro-5-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401212 CHEMBL2024195 Bioactive [4-[2-(2,5-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone
CFAMM00401225 CHEMBL2022785 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chloro-3-methylphenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401231 CHEMBL2022789 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401211 CHEMBL2024194 Bioactive [4-[2-(3,4-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone
CFAMM00401230 CHEMBL2023207 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chloro-2-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401223 CHEMBL2023210 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3-chloro-4-fluorophenyl)pyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401229 CHEMBL2023205 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3,4-difluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAMM00401235 CHEMBL2022786 Bioactive [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chloro-2-methylphenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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