Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
CFAM Family ID CFFBM10311 Family Name Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3-chlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone family No. of Seeds 20
No. of Other Members 13
Family Centroid CFAMM00401202 Functional Category Bioactive
Superfamily Lysosomal Pro-X carboxypeptidase Binder Superfamily 3 Class Class 213
Cousin Family Names Seeds Members 5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212 Cannabinoid receptor 1 Ligand Rimonabant Family 20 260 Cannabinoid receptor 1 Ligand TM38837 Family 20 15 Kinase and DNAPKi Inhibitor CC-115 Family 1 1 TGF-beta receptor type-1 Ligand LY2157299 Family 13 56 Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162 Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10 cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22 Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 2 Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 7 19 Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59 P2X purinoceptor 7 inhibitor N-[(2-chloro-3,4-difluorophenyl)m... 6 64 P2X purinoceptor 7 inhibitor N-[[2-chloro-3-(trifluoromethyl)p... 3 10 Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6 5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5 Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 16 Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13 Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21 Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3 5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4 Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7 Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21 D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1 Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 2 19 Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6 Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4 Cannabinoid receptor 1 ligand SureCN4819820 family 11 5 Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 4 15 Lysosomal Pro-X carboxypeptidase inhibitor [4-[2-(3-chloro-4-f... 5 0 Lysosomal Pro-X carboxypeptidase inhibitor [(1R,2R,4S)-4-amino... 9 0 Coagulation factor X inhibitor SureCN8169809 family 12 18 Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13 Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5 Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8 Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6 Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2 Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0 Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4 Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2 Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1 Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0 Cannabinoid receptor 1 ligand AGN-PC-07R5TU family 11 0 Cannabinoid receptor 1 ligand AGN-PC-07NHI2 family 4 1 Cannabinoid receptor 1 ligand AGN-PC-07RA3R family 15 0 Cannabinoid receptor 1 ligand SureCN3822127 family 5 0 Cannabinoid receptor 1 ligand AGN-PC-07R6QS family 5 0 Dipeptidyl peptidase 4 inhibitor (3R)-3-amino-1-(3-methyl-6,7-... 6 1 Dipeptidyl peptidase 4 inhibitor (3R)-3-amino-1-[3-(4-chloroph... 2 0 P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00401223 CHEMBL2023210 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3-chloro-4-fluorophenyl)pyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401229 CHEMBL2023205 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3,4-difluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401235 CHEMBL2022786 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chloro-2-methylphenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401228 CHEMBL2023202 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(2,5-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401208 CHEMBL2022793 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3,4-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401234 CHEMBL2022787 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3-chloro-4-methylphenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401214 CHEMBL2024197 Bioactive
[4-[2-(3-chloro-4-fluorophenyl)pyrazol-3-yl]piperidin-1-yl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone CFAMM00401227 CHEMBL2023208 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chloro-3-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401233 CHEMBL2023211 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(5-chloro-2-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401213 CHEMBL2024196 Bioactive
[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone CFAMM00401226 CHEMBL2023209 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401206 CHEMBL2022794 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(2,4-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401232 CHEMBL2023212 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(2-chloro-5-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401212 CHEMBL2024195 Bioactive
[4-[2-(2,5-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone CFAMM00401225 CHEMBL2022785 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chloro-3-methylphenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401231 CHEMBL2022789 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401211 CHEMBL2024194 Bioactive
[4-[2-(3,4-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]-[(3S,4R)-4-(2,4-difluorophenyl)pyrrolidin-3-yl]methanone CFAMM00401230 CHEMBL2023207 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(4-chloro-2-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00401219 CHEMBL2031594 Bioactive
[(1S,2S,4S)-4-amino-2-(2,4-difluorophenyl)-4-methylcyclopentyl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401216 CHEMBL1649666 Bioactive
SureCN3136300 CFAMM00401209 CHEMBL2218353 Bioactive
SureCN1194918 CFAMM00401222 CHEMBL1649674 Bioactive
SureCN4746431 CFAMM00401215 CHEMBL400595 Bioactive
[(3S,4R)-4-(4-chlorophenyl)-1-propan-2-ylpyrrolidin-3-yl]-[4-[2-(pyrazol-1-ylmethyl)phenyl]piperazin-1-yl]methanone CFAMM00401207 CHEMBL2022792 Bioactive
[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[4-[2-(3,5-dichlorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401220 CHEMBL2031592 Bioactive
[(1S,2S,4R)-4-amino-2-(2,4-difluorophenyl)-4-methylcyclopentyl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone CFAMM00401205 CHEMBL2218350 Bioactive
SureCN1194917 CFAMM00401218 CHEMBL1649670 Bioactive
SureCN3134820 CFAMM00401224 CHEMBL402927 Bioactive
AGN-PC-00AK3A CFAMM00401217 CHEMBL1649667 Bioactive
SureCN3139716 CFAMM00401210 CHEMBL2218411 Bioactive
SureCN1195685 CFAMM00401221 CHEMBL2031593 Bioactive
[(1R,2R,4R)-4-amino-2-(2,4-difluorophenyl)-4-methylcyclopentyl]-[4-[2-(3-chloro-4-fluorophenyl)-5-methylpyrazol-3-yl]piperidin-1-yl]methanone
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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