CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10349
Family Name Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)isoquinolin-4-yl]acetic acid family
No. of Seeds 4 No. of Other Members 9
Family Centroid CFAMM00401420 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and Prostaglandin D2 receptor 2 Binder Superfamily
Class Class 3182

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Substance-P receptor Ligand GSK424887 Family 8 184
Coagulation factor X Inhibitor Otamixaban Family 9 21
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Transient receptor potential cation channel subfamily V member... 6 23
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Cholecystokinin receptor type A ligand A-65186 family 2 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 6
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[[(E)-3-(3,4-dichlo... 6 1
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 7 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 2 1
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
Gastrin/cholecystokinin type B receptor ligand (2R)-2-[[5-(8-a... 2 3
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Angiotensin-converting enzyme and Endothelin-converting enzyme... 1 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401415 CHEMBL2023641 Bioactive 2-[1-[4-(1H-indole-2-carbonylamino)benzoyl]isoquinolin-4-yl]acetic acid
CFAMM00401420 CHEMBL2023638 Bioactive 2-[1-(4-benzamidobenzoyl)isoquinolin-4-yl]acetic acid
CFAMM00401418 CHEMBL2023647 Bioactive 2-[1-[4-[[4-(trifluoromethyl)benzoyl]amino]benzoyl]isoquinolin-4-yl]acetic acid
CFAMM00401416 CHEMBL2023640 Bioactive 2-[1-[4-(naphthalene-2-carbonylamino)benzoyl]isoquinolin-4-yl]acetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48692 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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