CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10362
Family Name Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-methylpiperazine family
No. of Seeds 4 No. of Other Members 23
Family Centroid CFAMM00401492 Functional Category Bioactive
Superfamily Dipeptidyl peptidase 4 and Ribosyldihydronicotinamide dehydrogenase [quinone] Binder Superfamily
Class Class 1440

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Calmodulin Inhibitor Aprindine Family 1 4
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Potassium voltage-gated channel subfamily A member 3 Ligand CP... 4 26
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 4
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
Androgen receptor ligand 4-[(1R,5R)-3-hydroxy-3-methyl-8-azabi... 8 7
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Lysosomal Pro-X carboxypeptidase and Glutamate receptor ionotr... 1 0
Sigma non-opioid intracellular receptor 1 and Sodium-dependent... 2 1
Cholinesterase inhibitor 10-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401491 CHEMBL2023824 Bioactive 1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-ethylpiperazine
CFAMM00401490 CHEMBL2023825 Bioactive 1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-cyclohexylpiperazine
CFAMM00401492 CHEMBL2023823 Bioactive 1-[4-[1-adamantyl(phenyl)methyl]phenyl]-4-methylpiperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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