CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10366
Family Name ALK tyrosine kinase receptor and Insulin-like growth factor 1 receptor ligand (3S)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide family
No. of Seeds 1 No. of Other Members 4
Family Centroid CFAMM00401507 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Inhibitor Bay 80-6946 Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Tyrosine-protein kinase SYK Inhibitor R788 Family 3 7
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
MK-6096 family 3 69
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-00EQPZ fa... 3 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Glycogen synthase kinase-3 alpha and Casein kinase II subunit ... 1 16
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Dihydrofolate reductase inhibitor 2-bromo-N-[4-[4-[(2,4-diamin... 1 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Insulin-like growth factor 1 receptor ligand AGN-PC-044T61 family 1 0
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401507 CHEMBL2023990 Bioactive (3S)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1-[2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]piperidine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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