CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10372
Family Name Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4-(7-methyl-1H-indazol-5-yl)-3-pyridin-2-ylbutanoyl]piperidin-4-yl]-1,4-dihydroquinazolin-2-one family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00401524 Functional Category Bioactive with Natural Product
Superfamily Calcitonin gene-related peptide type 1 receptor and Cytochrome P450 2D6 Ligand BMS-694153 Superfamily
Class Class 843

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 4
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 2 1
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 3 0
Calcitonin gene-related peptide type 1 receptor ligand [2-(7-m... 14 0
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN2... 11 0
Calcitonin gene-related peptide type 1 receptor ligand [(2R)-3... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401526 CHEMBL2024588 Bioactive 3-[1-[3-[5-(hydroxymethyl)pyridin-2-yl]-4-(7-methyl-1H-indazol-5-yl)butanoyl]piperidin-4-yl]-1,4-dihydroquinazolin-2-one
CFAMM00401525 CHEMBL2024589 Bioactive 6-[1-(7-methyl-1H-indazol-5-yl)-4-oxo-4-[4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidin-1-yl]butan-2-yl]pyridine-3-carbaldehyde
CFAMM00401524 CHEMBL2024170 Bioactive 3-[1-[4-(7-methyl-1H-indazol-5-yl)-3-pyridin-2-ylbutanoyl]piperidin-4-yl]-1,4-dihydroquinazolin-2-one
CFAMM00401523 CHEMBL2024173 Bioactive 3-[1-[4-(7-methyl-1H-indazol-5-yl)-3-(3-methylpyridin-2-yl)butanoyl]piperidin-4-yl]-1,4-dihydroquinazolin-2-one
CFAMM00401522 CHEMBL2024172 Bioactive 3-[1-[3-(4-ethylpyridin-2-yl)-4-(7-methyl-1H-indazol-5-yl)butanoyl]piperidin-4-yl]-1,4-dihydroquinazolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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