CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10379
Family Name D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]acetamide family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00401572 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 19
Class Class 2396

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Motilin receptor Ligand GSK962040 Family 30 457
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 23
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Histamine H3 receptor Ligand VUF-10214 Family 3 7
Phospholipase D1 Inhibitor Halopemide Family 17 111
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 34
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 6
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 8 24
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-5-amino-2-c... 3 4
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
C-C chemokine receptor type 2 and C-C chemokine receptor type ... 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Equilibrative nucleoside transporter 1 inhibitor Draflazine fa... 1 8
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 7 4
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
C-C chemokine receptor type 5 ligand AC1MHYGF family 3 2
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-(2-... 1 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GBV family 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Kappa-type opioid receptor ligand AGN-PC-077Q4Y family 5 9
Urotensin-2 receptor and Cytochrome P450 2D6 ligand 2-[3,4-dic... 2 3
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 6,7-dichlo... 2 0
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
5-hydroxytryptamine receptor 2C ligand SureCN5872545 family 3 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 14 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor ligand AGN-PC-00NCMY family 2 1
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Progesterone receptor ligand CHEMBL403139 family 2 0
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 0
Somatostatin receptor type 1 ligand AGN-PC-078XL4 family 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Metabotropic glutamate receptor 5 and Beta-lactamase ligand 2-... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 1
P2X purinoceptor 7 inhibitor SureCN3720401 family 1 0
Aminopeptidase N inhibitor (2S)-2-[(2-chlorophenyl)carbamoylam... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401572 CHEMBL2024514 Bioactive N-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]acetamide
CFAMM00401571 CHEMBL2024513 Bioactive N-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-2,2,2-trifluoroacetamide
CFAMM00401573 CHEMBL2024516 Bioactive N-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46256 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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