CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10381
Family Name D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-188 HCL family
No. of Seeds 8 No. of Other Members 0
Family Centroid CFAMM00375582 Functional Category Bioactive
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily 19
Class Class 2396

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Dopamine receptor Ligand Domperidone Family 2 21
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 34
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 4 18
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C8 inhib... 6 5
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
Melanin-concentrating hormone receptor 1 ligand 1-[(6S)-6-(3-c... 7 18
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 8 24
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 13 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-5-amino-2-c... 3 4
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
C-C chemokine receptor type 2 and C-C chemokine receptor type ... 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Melanin-concentrating hormone receptor 1 ligand 1-[[4-[4-(3-cy... 14 23
Melanin-concentrating hormone receptor 1 ligand SureCN3845324 ... 7 4
Melanin-concentrating hormone receptor 1 ligand SureCN14265737... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN14265866... 11 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00CYMY ... 1 0
Inosine-5'-monophosphate dehydrogenase inhibitor 1-(3,4-dichlo... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-(2-... 1 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 4 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 14 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Neuropeptide Y receptor type 5 ligand 3-[1-(3,5-dichlorophenyl... 1 0
Neuropeptide Y receptor type 5 ligand SureCN6214451 family 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
Melanin-concentrating hormone receptor 1 ligand N-[1-[3-(4-chl... 1 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-07C0GW family 1 0
DNA polymerase III PolC-type inhibitor 6-(3-chloro-4-methylani... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401579 CHEMBL2024675 Bioactive 3-[4-[2-[4-(2,5-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27070 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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