CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10382
Family Name Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7-methyl-1H-indazol-5-yl)-1-(6-methylpyridin-2-yl)ethyl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00401581 Functional Category Bioactive
Superfamily Calcitonin gene-related peptide type 1 receptor and Cytochrome P450 2D6 Ligand BMS-694153 Superfamily
Class Class 843

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 12 108
Transient receptor potential cation channel subfamily V member... 15 457
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Aurora kinase A Inhibitor ABT-348 Family 20 49
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
PF-4217903 family 14 65
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 3A4 Inhibitor 5-(2-phenethylpiperazin-1-yl)-1h... 12 35
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 5 11
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 20
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 2 1
Calcitonin gene-related peptide type 1 receptor ligand 2-[(7-m... 3 0
Calcitonin gene-related peptide type 1 receptor ligand [2-(7-m... 14 0
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Fibroblast growth factor receptor 1 and Vascular endothelial g... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Pol polyprotein inhibitor AC1LAMOI family 12 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN2... 11 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Calcitonin gene-related peptide type 1 receptor ligand [(2R)-3... 2 0
Cell division cycle 7-related protein kinase and Dual specific... 3 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
P2X purinoceptor 7 inhibitor N-cyano-N'-(2-methylphenyl)-4-[2-... 2 1
TGF-beta receptor type-1 ligand SureCN373106 family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401581 CHEMBL2024601 Bioactive N-[2-(7-methyl-1H-indazol-5-yl)-1-(6-methylpyridin-2-yl)ethyl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide
CFAMM00401587 CHEMBL2024596 Bioactive N-[2-(7-methyl-1H-indazol-5-yl)-1-quinolin-2-ylethyl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide
CFAMM00401586 CHEMBL2024594 Bioactive N-[1-(6-bromopyridin-2-yl)-2-(7-methyl-1H-indazol-5-yl)ethyl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide
CFAMM00401584 CHEMBL2024592 Bioactive N-[2-(7-methyl-1H-indazol-5-yl)-1-pyridin-2-ylethyl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide
CFAMM00401583 CHEMBL2024598 Bioactive N-[1-isoquinolin-3-yl-2-(7-methyl-1H-indazol-5-yl)ethyl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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