CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1039
Family Name Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform inhibitor pyrazolo pyrimidine, 28 family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00318658 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Binder Superfamily 4
Class Class 3274

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
HER Inhibitor AC480 Family 4 67
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
JAK Inhibitor Momelotinib Family 33 83
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Adenosine kinase inhibitor GP683 family 12 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 25 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Beta-3 adrenergic receptor ligand N-[4-[2-[[(2R)-2-hydroxy-2-p... 2 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 5
Neuropeptide Y receptor type 5 ligand 3-pyridin-2-yl-8-[[(5-py... 2 0
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Adenosine kinase inhibitor N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-... 4 1
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Serine/threonine-protein kinase mTOR inhibitor SureCN3776855 f... 1 0
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 3 2
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Tyrosine-protein kinase JAK2 inhibitor [4-[[5-(1-ethylpyrazol-... 2 3
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Mitogen-activated protein kinase 14 inhibitor SureCN294394 family 2 6
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00318659 CHEMBL1098245 Bioactive SureCN3986722
CFAMM00318658 CHEMBL558955 Bioactive pyrazolo pyrimidine, 28

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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