CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10405
Family Name Arachidonate 5-lipoxygenase-activating protein inhibitor methyl 2-[(1S,3R,4S)-3-phenyl-3-bicyclo[2.2.1]heptanyl]-4-(quinolin-2-ylmethoxy)benzoate family
No. of Seeds 12 No. of Other Members 3
Family Centroid CFAMM00401689 Functional Category Bioactive
Superfamily Arachidonate 5-lipoxygenase-activating protein Binder Superfamily
Class Class 3578

Cousin Family NamesSeedsMembers
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Leukotriene B4 receptor 1 Ligand SB-209247 Family 7 24
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cysteinyl leukotriene receptor 1 ligand 4-[(2S)-2-[[7-(quinoli... 6 15
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Arachidonate 5-lipoxygenase inhibitor (2E)-2-[2-butyl-1-[4-(qu... 1 12
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Cysteinyl leukotriene receptor 1 ligand 7-[[3-(quinolin-2-ylme... 7 5
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-met... 3 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 5-[2-... 7 1
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 3 5
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Insulin-like growth factor-binding protein 3 inhibitor (1E)-1-... 2 0
Cysteinyl leukotriene receptor 1 ligand 4-oxo-7-[[3-(quinolin-... 4 17
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Cysteinyl leukotriene receptor 1 ligand 6-bromo-4-oxo-3-(quino... 3 1
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0
Nuclear receptor ROR-gamma and Ras-related protein Rab-9A liga... 1 0
Proline--tRNA ligase, cytoplasmic inhibitor AC1NQN4X family 1 0
DNA polymerase beta and Microtubule-associated protein tau inh... 1 1
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3
3-quinolin-2-ylchromen-2-one NP ZINC08690002 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401698 CHEMBL2031436 Bioactive methyl 2-[(1S,3S,4S)-3-(2-fluorophenyl)-3-bicyclo[2.2.1]heptanyl]-4-(quinolin-2-ylmethoxy)benzoate
CFAMM00401689 CHEMBL2029369 Bioactive methyl 2-[(1S,3R,4S)-3-phenyl-3-bicyclo[2.2.1]heptanyl]-4-(quinolin-2-ylmethoxy)benzoate
CFAMM00401695 CHEMBL2031443 Bioactive methyl 2-[(1S,3R,4S)-3-(3,5-dimethylphenyl)-3-bicyclo[2.2.1]heptanyl]-4-(quinolin-2-ylmethoxy)benzoate
CFAMM00401694 CHEMBL2031442 Bioactive methyl 2-[(1S,3R,4S)-3-(3,5-difluorophenyl)-3-bicyclo[2.2.1]heptanyl]-4-(quinolin-2-ylmethoxy)benzoate
CFAMM00401693 CHEMBL2031441 Bioactive methyl 2-[(1S,3R,4S)-3-(3-methoxyphenyl)-3-bicyclo[2.2.1]heptanyl]-4-(quinolin-2-ylmethoxy)benzoate
CFAMM00401686 CHEMBL2031437 Bioactive methyl 2-[(1S,3R,4S)-3-(3-fluorophenyl)-3-bicyclo[2.2.1]heptanyl]-4-(quinolin-2-ylmethoxy)benzoate
CFAMM00401692 CHEMBL2031440 Bioactive methyl 4-(quinolin-2-ylmethoxy)-2-[(1S,3R,4S)-3-[3-(trifluoromethyl)phenyl]-3-bicyclo[2.2.1]heptanyl]benzoate
CFAMM00401685 CHEMBL254564 Bioactive SureCN3582518
CFAMM00401700 CHEMBL2031438 Bioactive methyl 2-[(1S,3R,4S)-3-(4-fluorophenyl)-3-bicyclo[2.2.1]heptanyl]-4-(quinolin-2-ylmethoxy)benzoate
CFAMM00401691 CHEMBL2031453 Bioactive methyl 2-(3-methyl-1-phenylcyclobutyl)-4-(quinolin-2-ylmethoxy)benzoate
CFAMM00401699 CHEMBL2031439 Bioactive methyl 2-[(1S,3R,4S)-3-(3-methylphenyl)-3-bicyclo[2.2.1]heptanyl]-4-(quinolin-2-ylmethoxy)benzoate
CFAMM00401690 CHEMBL2031455 Bioactive methyl 2-(3,3-dimethyl-1-phenylcyclobutyl)-4-(quinolin-2-ylmethoxy)benzoate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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