CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10412
Family Name Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-phenyl-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide family
No. of Seeds 9 No. of Other Members 3
Family Centroid CFAMM00401752 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Dual specificity protein kinase TTK Binder Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Tyrosine-protein kinase SYK Inhibitor R788 Family 3 7
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
AP26113 family 16 90
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Mitogen-activated protein kinase 14 Inhibitor Pamapimod Family 15 7
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Lysine--tRNA ligase and Tyrosine-protein kinase Lyn inhibitor ... 1 0
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401753 CHEMBL2029437 Bioactive N-[3-[7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-naphthalen-2-yl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide
CFAMM00401748 CHEMBL2029439 Bioactive N-[3-[7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-(4-phenylphenyl)-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide
CFAMM00401752 CHEMBL2029436 Bioactive N-[3-[7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-phenyl-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide
CFAMM00401747 CHEMBL2029438 Bioactive N-[3-[3-benzyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide
CFAMM00401751 CHEMBL2029435 Bioactive N-[3-[3-cyclopropyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide
CFAMM00401750 CHEMBL2029431 Bioactive N-[3-[3-methyl-7-[4-(4-methylpiperazin-1-yl)-2-propan-2-yloxyanilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide
CFAMM00401743 CHEMBL2029440 Bioactive N-[3-[7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-(4-phenoxyphenyl)-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide
CFAMM00401749 CHEMBL2029430 Bioactive N-[3-[7-[2-ethoxy-4-(4-methylpiperazin-1-yl)anilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide
CFAMM00401742 CHEMBL2029441 Bioactive N-[3-[7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-(4-phenylmethoxyphenyl)-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27038 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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