CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10413
Family Name Plasma kallikrein and Coagulation factor VII inhibitor 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-4-oxo-5-phenylcyclohexa-1,5-dien-1-yl]butanedioic acid family
No. of Seeds 15 No. of Other Members 49
Family Centroid CFAMM00401780 Functional Category Bioactive
Superfamily Coagulation factor VII and Urokinase-type plasminogen activator Binder Superfamily
Class Class 931

Cousin Family NamesSeedsMembers
JNJ-39439335 family 5 11
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
NS5B protein inhibitor AGN-PC-00A17Z family 1 23
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Coagulation factor VII inhibitor 2-[(3E)-3-(5-carbamimidoyl-1,... 3 1
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1... 3 2
Coagulation factor VII and Tissue factor inhibitor AGN-PC-00R9... 2 10
Coagulation factor VII inhibitor AGN-PC-0763KB family 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Coagulation factor X and Urokinase-type plasminogen activator ... 8 10
Coagulation factor VII and Tissue factor inhibitor 2-[3-(5-car... 3 2
Coagulation factor X and Prothrombin inhibitor SureCN6292901 f... 2 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401768 CHEMBL426675 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(2-hydroxy-5-nitrophenyl)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401807 CHEMBL202945 Bioactive 2-[[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(5-fluoro-2-hydroxyphenyl)-4-oxocyclohexa-1,5-dien-1-yl]methyl]butanedioic acid
CFAMM00401780 CHEMBL206069 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-4-oxo-5-phenylcyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401786 CHEMBL377082 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(5-fluoro-2-hydroxyphenyl)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401799 CHEMBL379906 Bioactive 2-[(3E)-5-(3-acetylphenyl)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401811 CHEMBL205128 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(3-cyanophenyl)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401791 CHEMBL204283 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(2-methylphenyl)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401804 CHEMBL383269 Bioactive 2-[(3E)-5-(5-amino-2-hydroxyphenyl)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401784 CHEMBL206387 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-[5-[(carbamoylamino)methyl]-2-hydroxyphenyl]-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401764 CHEMBL206454 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(3-carbamoylphenyl)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401777 CHEMBL206168 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(5-fluoro-2-hydroxyphenyl)-4-oxocyclohexa-1,5-dien-1-yl]acetic acid
CFAMM00401770 CHEMBL382418 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(3-hydroxyphenyl)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401769 CHEMBL381120 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(2-methoxyphenyl)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401762 CHEMBL204614 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(3-methoxyphenyl)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid
CFAMM00401788 CHEMBL205208 Bioactive 2-[(3E)-3-(5-carbamimidoyl-1,3-dihydrobenzimidazol-2-ylidene)-5-(3-methylphenyl)-4-oxocyclohexa-1,5-dien-1-yl]butanedioic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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