CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10414
Family Name Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiazol-5-yl)-3-[(1S)-1-quinolin-6-ylethyl]triazolo[4,5-c]pyridin-4-one family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00401822 Functional Category Bioactive
Superfamily Cannabinoid receptor 1 and Histone deacetylase 1 Binder Superfamily
Class Class 1276

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Melanin-concentrating hormone receptor 1 ligand SureCN10144515... 3 6
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor SBC family 5 18
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-075CD... 2 8
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
TGF-beta receptor type-1 ligand SureCN373106 family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401821 CHEMBL2029682 Bioactive 5-(5-methylthiophen-2-yl)-3-[(1S)-1-quinolin-6-ylethyl]triazolo[4,5-c]pyridin-4-one
CFAMM00401820 CHEMBL2029683 Bioactive 5-(1-methylpyrazol-4-yl)-3-[(1S)-1-quinolin-6-ylethyl]triazolo[4,5-c]pyridin-4-one
CFAMM00401824 CHEMBL2029561 Bioactive 5-(3-methyl-1,2-thiazol-5-yl)-3-(quinolin-6-ylmethyl)triazolo[4,5-c]pyridin-4-one
CFAMM00401823 CHEMBL2029681 Bioactive 5-(4-methylthiophen-2-yl)-3-[(1S)-1-quinolin-6-ylethyl]triazolo[4,5-c]pyridin-4-one
CFAMM00401822 CHEMBL2029564 Bioactive 5-(3-methyl-1,2-thiazol-5-yl)-3-[(1S)-1-quinolin-6-ylethyl]triazolo[4,5-c]pyridin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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