CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10442
Family Name Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-fluorophenyl)-3-hydroxybutan-2-yl]acetamide family
No. of Seeds 34 No. of Other Members 23
Family Centroid CFAMM00402223 Functional Category Bioactive
Superfamily Beta-secretase 1 and Cathepsin D Binder Superfamily 4
Class Class 284

Cousin Family NamesSeedsMembers
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand (2r)-... 18 30
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 4
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)... 3 5
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 15 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Renin inhibitor SureCN7300793 family 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00402222 CHEMBL2030997 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402197 CHEMBL2407492 Bioactive CHEMBL2407492
CFAMM00402215 CHEMBL2151236 Bioactive N-[(2S,3R)-1-(2,4-difluorophenyl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00402190 CHEMBL2151240 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-[4-fluoro-3-(trifluoromethoxy)phenyl]-3-hydroxybutan-2-yl]acetamide
CFAMM00402206 CHEMBL2031146 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-1',1'-difluorospiro[3,4-dihydropyrano[2,3-b]pyridine-2,3'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402221 CHEMBL2030994 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-3'-fluorospiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402170 CHEMBL2407487 Bioactive (10S)-10-[(1R)-2-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-hydroxyethyl]-9-azabicyclo[10.3.1]hexadeca-1(16),12,14-trien-8-one
CFAMM00402196 CHEMBL2407491 Bioactive CHEMBL2407491
CFAMM00402214 CHEMBL2151151 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]acetamide
CFAMM00402163 CHEMBL2181905 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-ethynyl-4-fluorophenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
CFAMM00402189 CHEMBL2151241 Bioactive N-[(2S,3R)-1-(3-cyano-4-fluorophenyl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00402202 CHEMBL2031148 Bioactive CHEMBL2031147
CFAMM00402220 CHEMBL2030995 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-3'-fluorospiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402182 CHEMBL2031151 Bioactive N-[(2R,3S)-1-[[(4S)-6-(2,2-dimethylpropyl)-3'-hydroxyspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-2-hydroxyhex-5-en-3-yl]acetamide
CFAMM00402195 CHEMBL2031000 Bioactive N-[(2S,3R)-4-[[(2S,2'S,4S)-6-(2,2-dimethylpropyl)-2'-methylspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402213 CHEMBL2151152 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(2-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402188 CHEMBL2151242 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluoro-3-methoxyphenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402201 CHEMBL2031149 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-3'-hydroxyspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
CFAMM00402219 CHEMBL2030998 Bioactive N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00402168 CHEMBL2171307 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
CFAMM00402181 CHEMBL2031150 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-3'-hydroxyspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]-2-fluoroacetamide
CFAMM00402187 CHEMBL2151243 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-fluoro-4-methylphenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402211 CHEMBL2151238 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluoro-3-methylphenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402224 CHEMBL2177107 Bioactive N-[(2S,3R)-3-hydroxy-4-[[(4S)-6-(2-methylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-phenylbutan-2-yl]acetamide
CFAMM00402186 CHEMBL2181896 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-ethynylphenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
CFAMM00402217 CHEMBL2151235 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(trifluoromethyl)phenyl]butan-2-yl]acetamide
CFAMM00402166 CHEMBL2181906 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-ethynyl-5-fluorophenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
CFAMM00402210 CHEMBL2031142 Bioactive N-[(2S,3R)-1-(3,4-difluorophenyl)-4-[[(4S)-6-(2,2-dimethylpropyl)-3'-methylspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00402223 CHEMBL2030996 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402198 CHEMBL2407339 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-(3-prop-2-enylphenyl)butan-2-yl]hex-5-enamide
CFAMM00402216 CHEMBL2151237 Bioactive N-[(2S,3R)-1-(3,4-difluorophenyl)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxybutan-2-yl]acetamide
CFAMM00402165 CHEMBL2181907 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(5-ethynyl-2-fluorophenyl)-3-hydroxybutan-2-yl]-2-methoxyacetamide
CFAMM00402208 CHEMBL2031140 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)-3'-methylspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(4-fluorophenyl)-3-hydroxybutan-2-yl]acetamide
CFAMM00402191 CHEMBL2151244 Bioactive N-[(2S,3R)-4-[[(4S)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-1-(3-fluoro-4-methoxyphenyl)-3-hydroxybutan-2-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Professor in Department of Pharmacy
National University of Singapore, Singapore


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