CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10453
Family Name Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(2S,3R)-3-methyl-1-(2-methyl-5-phenyl-1,3-thiazole-4-carbonyl)piperidin-2-yl]methyl]quinoline-8-carboxamide family
No. of Seeds 9 No. of Other Members 5
Family Centroid CFAMM00376628 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 1 and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 3795

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Cyclin-dependent kinase 5 Inhibitor 3-(2-phenylthiazol-4-yl)qu... 2 44
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 4 8
Cysteine protease and Cruzipain inhibitor N-[(E,3S)-1-(benzene... 1 1
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1231206 ... 6 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cellular tumor antigen p53 and Ferritin light chain inhibitor ... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzyls... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 13
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 0
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Coagulation factor X inhibitor N-[5-carbamoyl-2-[[(5-chlorothi... 8 8
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Prothrombin inhibitor (3R,6S,8aS)-N-[5-(diaminomethylideneamin... 2 3
Coagulation factor X inhibitor 2-[4-[(5-chloro-1H-indole-2-car... 4 0
Metabotropic glutamate receptor 1 ligand AGN-PC-046KML family 7 40
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 13 37
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9TG5 family 11 10
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9S6C family 10 1
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Coagulation factor X inhibitor AGN-PC-030DHH family 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X1L ... 1 3
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 5 5
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
D(3) dopamine receptor ligand N-[4-[2-[[(6S)-2-amino-4,5,6,7-t... 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Metabotropic glutamate receptor 1 ligand SureCN8238697 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(6-morp... 2 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 1 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Gamma-aminobutyric acid receptor subunit alpha-2 and Gamma-ami... 6 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 1 4
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 1 0
Coagulation factor X inhibitor SureCN1251046 family 3 0
Coagulation factor X inhibitor N-[(1R,2S,5S)-2-[(5-bromo-1H-in... 1 1
Coagulation factor X inhibitor SureCN1253902 family 2 0
Metabotropic glutamate receptor 5 ligand 2-(2-pyridin-3-ylethy... 1 2
Calpain-1 catalytic subunit inhibitor 2,5-dichloro-N-[(2S)-3,4... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00402297 CHEMBL2417798 Bioactive N-[4-[1-(4-methyl-1,3-thiazole-5-carbonyl)piperidin-4-yl]butyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CFAMM00402294 CHEMBL2031482 Bioactive N-[[1-(2-methyl-4-phenyl-1,3-thiazole-5-carbonyl)piperidin-2-yl]methyl]quinoline-8-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26194 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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