CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10466
Family Name Melanin-concentrating hormone receptor 1 and 5-hydroxytryptamine receptor 2C ligand 4-(4-chlorophenyl)-N-[3-(pyrrolidin-1-ylmethyl)quinolin-7-yl]piperidine-1-carboxamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00256712 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and 5-hydroxytryptamine receptor 1B Binder Superfamily
Class Class 471

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
D(2) dopamine receptor Ligand Sertindole Family 3 173
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 16 295
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Transient receptor potential cation channel subfamily V member... 15 457
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Amg 423 family 7 47
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
ABC294640 family 5 75
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Urotensin-2 receptor Ligand Palosuran Family 4 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
Melanin-concentrating hormone receptor 1 ligand AGN-PC-08W6BO ... 2 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Melanin-concentrating hormone receptor 1 ligand SureCN11425142... 3 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 7 14
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 4
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN7073167 family 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Transient receptor potential cation channel subfamily V member... 2 0
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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