CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10474
Family Name Histamine H3 receptor ligand 6-[[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-oxo-3,4-dihydroisoquinolin-6-yl]oxy]pyridine-3-carbonitrile family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00402386 Functional Category Bioactive
Superfamily Delta-type opioid receptor and Mu-type opioid receptor Ligand 6-(2-phenethylisoindolin-5-yloxy)nicotinamide Superfamily
Class Class 2449

Cousin Family NamesSeedsMembers
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Histamine H3 receptor and Potassium voltage-gated channel subf... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 2
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Growth hormone secretagogue receptor type 1 and Potassium volt... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 2 1
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
Platelet-activating factor receptor ligand [(2R,4R)-4-(octadec... 3 2
Reverse transcriptase/RNaseH inhibitor 3Am-6Et-7,9-diMe-PBOA-5... 4 1
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9RLJ family 1 0
Collagenase 3 inhibitor 4-[4-[2-[(3S)-3-hydroxy-1-azabicyclo[2... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00402385 CHEMBL2031864 Bioactive 5-[[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-oxo-3,4-dihydroisoquinolin-6-yl]oxy]pyridine-2-carbonitrile
CFAMM00402386 CHEMBL2031863 Bioactive 6-[[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-oxo-3,4-dihydroisoquinolin-6-yl]oxy]pyridine-3-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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