CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10492
Family Name Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate receptor 3 ligand 1-[2-[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazol-5-yl]ethyl]piperidine-4-carboxylic acid family
No. of Seeds 14 No. of Other Members 24
Family Centroid CFAMM00067723 Functional Category Bioactive
Superfamily Sphingosine 1-phosphate receptor 1 and Aldose reductase Binder Superfamily
Class Class 994

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Egl nine homolog 2 Inhibitor FG-4592 Family 1 4
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Benoxapr... 1 76
Peroxisome proliferator-activated receptor alpha Ligand Alegli... 29 7
Substance-P receptor Ligand R 673 Family 2 127
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Chymase Inhibitor Y-40613 Family 11 56
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Fatty-acid amide hydrolase 1 Inhibitor (z)-1-(benzo[d]oxazol-2... 2 27
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Oestrogen receptor and Estrogen receptor beta Ligand 2-naphtha... 4 51
Oestrogen receptor and Estrogen receptor beta Ligand 2-(6-hydr... 9 22
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Leukotriene A-4 hydrolase Inhibitor 2-[4-(2-azepan-1-ylethoxy)... 5 15
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 7
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Aldose reductase inhibitor SureCN1590315 family 1 7
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin E2 receptor EP4 subtype ligand SureCN4876498 family 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,4S)-4-f... 4 7
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Sphingosine 1-phosphate receptor 1 ligand AGN-PC-00DWQL family 2 2
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,5S)-5-(... 20 10
Inosine-5'-monophosphate dehydrogenase inhibitor 2-(2,3-dichlo... 2 0
Inosine-5'-monophosphate dehydrogenase inhibitor (2S)-2-(2,3-d... 4 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Cholesteryl ester transfer protein inhibitor 2-(4-chloro-2,3-d... 1 1
Peroxisome proliferator-activated receptor alpha ligand 5-[4-[... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2,6-di... 2 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 7 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
D(4) dopamine receptor ligand SureCN8704964 family 1 2
Cholesteryl ester transfer protein inhibitor AGN-PC-09QKST family 1 3
Glucocorticoid receptor and Progesterone receptor ligand (8S,1... 2 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 1 3
Cholesteryl ester transfer protein inhibitor AGN-PC-07R9U4 family 1 1
Arachidonate 5-lipoxygenase inhibitor (4E)-4-[(E,4Z)-4-(3H-1,3... 6 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00402484 CHEMBL2032438 Bioactive 1-[3-[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazol-5-yl]propyl]piperidine-3-carboxylic acid
CFAMM00402483 CHEMBL2032432 Bioactive 2-[1-[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazol-5-yl]piperidin-4-yl]acetic acid
CFAMM00402463 CHEMBL2032318 Bioactive 6-[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazol-5-yl]hexanoic acid
CFAMM00402482 CHEMBL2032431 Bioactive 1-[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazol-5-yl]piperidine-4-carboxylic acid
CFAMM00402480 CHEMBL2032435 Bioactive 2-[4-[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazol-5-yl]piperazin-1-yl]acetic acid
CFAMM00402479 CHEMBL2032433 Bioactive 2-[4-[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazol-5-yl]piperidin-1-yl]acetic acid
CFAMM00402485 CHEMBL2032439 Bioactive 1-[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1,3-benzoxazol-5-yl]azetidine-3-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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