Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
Cousin Family Names Seeds Members Cyclooxygenase Inhibitor Oxaprozin Family 33 450 Egl nine homolog 2 Inhibitor FG-4592 Family 1 4 Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Benoxapr... 1 76 Peroxisome proliferator-activated receptor alpha Ligand Alegli... 29 7 Substance-P receptor Ligand R 673 Family 2 127 C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52 Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94 Chymase Inhibitor Y-40613 Family 11 56 Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101 Fatty-acid amide hydrolase 1 Inhibitor (z)-1-(benzo[d]oxazol-2... 2 27 Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142 Oestrogen receptor and Estrogen receptor beta Ligand 2-naphtha... 4 51 Oestrogen receptor and Estrogen receptor beta Ligand 2-(6-hydr... 9 22 Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17 Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64 Leukotriene A-4 hydrolase Inhibitor 2-[4-(2-azepan-1-ylethoxy)... 5 15 Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16 Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4 Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6 Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13 Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 4 Peroxisome proliferator-activated receptor delta and Peroxisom... 2 7 Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19 Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2 Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25 Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21 Prelamin-A/C inhibitor CHEMBL1374443 family 1 6 Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12 B2 bradykinin receptor ligand SureCN6640854 family 7 4 Aldose reductase inhibitor SureCN1590315 family 1 7 Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37 Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12 Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5 Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1 Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12 Prostaglandin E2 receptor EP4 subtype ligand SureCN4876498 family 2 0 Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,4S)-4-f... 4 7 Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 1 Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1 Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3 Sphingosine 1-phosphate receptor 1 ligand AGN-PC-00DWQL family 2 2 Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 3 Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2 Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5 Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0 Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,5S)-5-(... 20 10 Inosine-5'-monophosphate dehydrogenase inhibitor 2-(2,3-dichlo... 2 0 Inosine-5'-monophosphate dehydrogenase inhibitor (2S)-2-(2,3-d... 4 1 Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1 Cholesteryl ester transfer protein inhibitor 2-(4-chloro-2,3-d... 1 1 Peroxisome proliferator-activated receptor alpha ligand 5-[4-[... 1 0 Peroxisome proliferator-activated receptor delta and Peroxisom... 1 0 D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3 Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2,6-di... 2 4 D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0 D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0 Peroxisome proliferator-activated receptor gamma and Peroxisom... 7 2 Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3 D(4) dopamine receptor ligand SureCN8704964 family 1 2 Cholesteryl ester transfer protein inhibitor AGN-PC-09QKST family 1 3 Glucocorticoid receptor and Progesterone receptor ligand (8S,1... 2 0 Protein farnesyltransferase subunit beta and Protein farnesylt... 1 3 Cholesteryl ester transfer protein inhibitor AGN-PC-07R9U4 family 1 1 Arachidonate 5-lipoxygenase inhibitor (4E)-4-[(E,4Z)-4-(3H-1,3... 6 6
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00402462
CHEMBL321840
Bioactive
AGN-PC-03H5YQ CFAMM00402475
CHEMBL1682469
Bioactive
AGN-PC-09QNA2 CFAMM00402481
CHEMBL110076
Bioactive
SureCN5835167 CFAMM00402455
CHEMBL495255
Bioactive
2-[3-[5-(4-fluorophenyl)-1,3-benzoxazol-2-yl]-4-(propylamino)phenyl]-1,3-dioxoisoindole-5-carboxylic acid CFAMM00402461
CHEMBL324195
Bioactive
AGN-PC-074XNZ CFAMM00402474
CHEMBL113254
Bioactive
AGN-PC-074XOJ CFAMM00402467
CHEMBL109657
Bioactive
SureCN5834648 CFAMM00402460
CHEMBL113565
Bioactive
SureCN5836192 CFAMM00402473
CHEMBL109419
Bioactive
AGN-PC-03H5ZX CFAMM00402466
CHEMBL112849
Bioactive
SureCN5834901 CFAMM00402472
CHEMBL195985
Bioactive
2-[2-[4-[[(E)-3-(4-cyanophenyl)prop-2-enoyl]amino]-3-fluorophenyl]-1,3-benzoxazol-5-yl]acetic acid CFAMM00402465
CHEMBL112101
Bioactive
AGN-PC-074XLK CFAMM00402458
CHEMBL194231
Bioactive
2-[2-[4-[(E)-3-(4-bromoanilino)-3-oxoprop-1-enyl]-2-fluorophenyl]-1,3-benzoxazol-5-yl]acetic acid CFAMM00402464
CHEMBL364476
Bioactive
2-[2-[4-[(E)-3-(4-cyanoanilino)-3-oxoprop-1-enyl]-2-fluorophenyl]-1,3-benzoxazol-5-yl]acetic acid CFAMM00402477
CHEMBL449422
Bioactive
1,3-dioxo-2-[4-(propylamino)-3-[5-[4-(trifluoromethoxy)phenyl]-1,3-benzoxazol-2-yl]phenyl]isoindole-5-carboxylic acid CFAMM00402457
CHEMBL321645
Bioactive
AGN-PC-03H5XJ CFAMM00402476
CHEMBL193625
Bioactive
2-[2-[4-[(E)-3-(3-bromoanilino)-3-oxoprop-1-enyl]-2-fluorophenyl]-1,3-benzoxazol-5-yl]acetic acid CFAMM00402456
CHEMBL112480
Bioactive
SureCN5835036 CFAMM00402468
CHEMBL1950694
Bioactive
(8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-11-(2-methyl-1,3-benzoxazol-5-yl)-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one CFAMM00402478
CHEMBL299020
Bioactive
2-[(3R)-2-[4-(1,3-benzoxazol-2-yl)phenyl]sulfonyl-3,4-dihydro-1H-isoquinolin-3-yl]-2-oxoacetic acid CFAMM00402471
CHEMBL138273
Bioactive
AGN-PC-074A8Z CFAMM00402470
CHEMBL1950697
Bioactive
(8S,11R,13S,14S,17S)-17-hydroxy-13-methyl-17-prop-1-ynyl-11-[2-(trifluoromethyl)-1,3-benzoxazol-5-yl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one CFAMM00402469
CHEMBL1950696
Bioactive
N-[(8S,11R,13S,14S,17S)-13-methyl-3-oxo-17-prop-1-ynyl-11-[2-(trifluoromethyl)-1,3-benzoxazol-5-yl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]formamide CFAMM00402459
57178660
Patent Compound
Statistics of CFAM Database
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong
Deputy
Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
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