CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10496
Family Name Vascular endothelial growth factor receptor 2 and Aurora kinase B ligand 6-(6,7-dimethoxyquinazolin-4-yl)oxynaphthalene-1-carboxamide family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00144522 Functional Category Bioactive
Superfamily Vascular endothelial growth factor receptor 2 and Cellular tumor antigen p53 Binder Superfamily
Class Class 211

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Tivozanib family 4 6
MK-6096 family 3 69
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 22
cAMP-specific 3',5'-cyclic phosphodiesterase 4C and cAMP-speci... 12 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Alpha-1A adrenergic receptor ligand 4-[4-(4-amino-6,7-dimethox... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Platelet-derived growth factor receptor beta and Macrophage co... 8 0
Platelet-derived growth factor receptor beta and Macrophage co... 7 0
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Hepatocyte growth factor receptor ligand 1-[(E)-(2,4-difluorop... 2 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Nuclear receptor ROR-gamma and Prelamin-A/C ligand ST50133141 ... 1 0
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 4 3
Extracellular calcium-sensing receptor ligand SureCN13996883 f... 1 8
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 1
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00402500 CHEMBL272823 Bioactive N-(4-chlorophenyl)-6-(6,7-dimethoxyquinazolin-4-yl)oxynaphthalene-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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