CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1051
Family Name Dihydroorotate dehydrogenase (quinone), mitochondrial inhibitor 3-N-benzyl-5-N-(4-carbamoylphenyl)-1-(4-chlorophenyl)pyrazole-3,5-dicarboxamide family
No. of Seeds 3 No. of Other Members 59
Family Centroid CFAMM00318756 Functional Category Bioactive
Superfamily Histidine decarboxylase Inhibitor Bf-derm1 Superfamily
Class Class 849

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Cannabinoid receptor 1 Ligand Rimonabant Family 20 260
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Cannabinoid receptor 1 Ligand TM38837 Family 20 15
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Coagulation factor X Inhibitor SN429 Family 23 100
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
P2X purinoceptor 7 inhibitor N-[(2-chloro-3,4-difluorophenyl)m... 6 64
P2X purinoceptor 7 inhibitor N-[[2-chloro-3-(trifluoromethyl)p... 3 10
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 16
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 2
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 2 19
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 1 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Cannabinoid receptor 1 ligand SureCN4819820 family 11 5
Cannabinoid receptor 1 and Peroxisome proliferator-activated r... 2 5
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Lysosomal Pro-X carboxypeptidase inhibitor [(1R,2R,4S)-4-amino... 9 0
Coagulation factor X inhibitor SureCN8169809 family 12 18
Coagulation factor X inhibitor SureCN8165148 family 4 0
Coagulation factor X inhibitor AGN-PC-0749DA family 3 2
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Coagulation factor X inhibitor DPC 423 derivative, 8 family 1 2
Mitogen-activated protein kinase 8 inhibitor 5-[(6-chloro-1-ox... 5 7
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
D(4) dopamine receptor and D(1A) dopamine receptor ligand 3-[[... 1 0
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 3 22
Cannabinoid receptor 1 ligand AGN-PC-07R5TU family 11 0
Cannabinoid receptor 1 ligand AGN-PC-07NHI2 family 4 1
Cannabinoid receptor 1 ligand AGN-PC-07RA6C family 21 2
Cannabinoid receptor 1 ligand AGN-PC-07RA3R family 15 0
Cannabinoid receptor 1 ligand SureCN3822127 family 5 0
Cannabinoid receptor 1 ligand 1-(2-chlorophenyl)-5-(4-chloroph... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QS family 5 0
P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6
P2X purinoceptor 7 inhibitor AGN-PC-0C7PCI family 1 10


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00318811 CHEMBL1098723 Bioactive 4-[4-[2-[(2-chloro-4-fluorophenyl)methylamino]-2-oxoethyl]-3,5-dimethylpyrazol-1-yl]benzamide
CFAMM00318779 CHEMBL143628 Bioactive 3-N-benzyl-1-(4-chlorophenyl)-5-N-phenylpyrazole-3,5-dicarboxamide
CFAMM00318756 CHEMBL342220 Bioactive 3-N-benzyl-5-N-(4-carbamoylphenyl)-1-(4-chlorophenyl)pyrazole-3,5-dicarboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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