CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10522
Family Name Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]propanamide family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00402609 Functional Category Bioactive
Superfamily Substance-P receptor and Neuromedin-K receptor Binder Superfamily
Class Class 1006

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
C-C chemokine receptor type 5 Ligand Vicriviroc Family 4 31
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Translocator protein Inhibitor Emapunil Family 7 89
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
PF-4136309 family 16 27
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Class II cytokine receptor Ligand IL-10 Family 7 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Neuromedin-K receptor and Substance-P receptor ligand AGN-PC-0... 18 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 5 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Microsomal triglyceride transfer protein large subunit inhibit... 7 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... 3 39
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-pyr... 5 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Substance-P receptor ligand Netupitant family 5 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Transient receptor potential cation channel subfamily V member... 57 4
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 4 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Translocator protein inhibitor CHEMBL2331870 family 2 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Beta-secretase 1 and Cathepsin D inhibitor (4R)-2'-amino-6-(2-... 2 3
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Calcitonin gene-related peptide type 1 receptor ligand N-[(2R)... 1 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Transient receptor potential cation channel subfamily V member... 1 0
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Collagenase 3 inhibitor MMP-13 Inhibitor family 1 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 11
Histone deacetylase 1 inhibitor AGN-PC-07ZGOS family 1 0
Corticotropin-releasing factor receptor 2 and Corticotropin-re... 2 1
Beta-lactamase inhibitor CHEMBL1497312 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00402609 CHEMBL203867 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]propanamide
CFAMM00402608 CHEMBL203605 Bioactive AGN-PC-0760FM
CFAMM00402607 CHEMBL381832 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[5-(2-methylphenyl)-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]propanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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