CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10530
Family Name Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 receptor EP2 subtype ligand 2-[2-[(2R)-2-[(E,3S)-4-[3-(1,3-benzoxazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00402643 Functional Category Bioactive
Superfamily Prostaglandin E2 receptor EP2 subtype and Prostaglandin E2 receptor EP4 subtype Binder Superfamily 3
Class Class 4711

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Peroxisome proliferator-activated receptor gamma Ligand SB-213... 2 54
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
Neutrophil elastase inhibitor 1-[4-(1,3-benzoxazol-2-ylsulfany... 3 0


External ID

Functional Category

Molecule Name

CFAMM00402647 CHEMBL2037290 Bioactive 2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(4-methyl-1,3-benzoxazol-2-yl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
CFAMM00402646 CHEMBL2037291 Bioactive 2-[2-[(2R)-2-[(E,3S)-4-[3-(5,7-dimethyl-1,3-benzoxazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
CFAMM00402645 CHEMBL2037292 Bioactive 2-[2-[(2R)-2-[(E,3S)-4-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
CFAMM00402644 CHEMBL2036312 Bioactive 4-[2-[(2R)-2-[(E,3S)-4-[3-(1,3-benzoxazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
CFAMM00402643 CHEMBL2036323 Bioactive 2-[2-[(2R)-2-[(E,3S)-4-[3-(1,3-benzoxazol-2-yl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
CFAMM00402642 CHEMBL2036326 Bioactive 2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
CFAMM00402648 CHEMBL2037289 Bioactive 2-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(6-methyl-1,3-benzoxazol-2-yl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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