CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10542
Family Name Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[2-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-oxoethyl]piperazine-1-carboxylate family
No. of Seeds 5 No. of Other Members 5
Family Centroid CFAMM00242336 Functional Category Bioactive
Superfamily Sodium channel protein type 5 subunit alpha Ligand Dyclonine Superfamily
Class Class 298

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Histamine H3 receptor and Histamine H2 receptor ligand N-[(3S)... 16 5
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Pol polyprotein inhibitor MDL 74538 family 11 1
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Histamine H3 receptor ligand SureCN7244264 family 1 0
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Capsid scaffolding protein inhibitor AC1LAC52 family 1 0
Histamine H3 receptor ligand 3-[[(1S,4S)-5-[3-[4-(cyclopropane... 1 3
Cathepsin K inhibitor benzyl N-[(2S)-4-methyl-1-oxo-1-[2-[[(4-... 2 0
NS3 inhibitor AC1NQTOZ family 2 0
oxybenzoate NP ZINC04029407 Family 4 1
NP Molport-006-318-109 Family 13 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00402699 CHEMBL2036657 Bioactive (4-fluorophenyl) 4-[2-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-oxoethyl]piperazine-1-carboxylate
CFAMM00402698 CHEMBL2036656 Bioactive phenyl 4-[2-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-2-oxoethyl]piperazine-1-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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