CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10543
Family Name Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]ethanone family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00242263 Functional Category Bioactive
Superfamily Sodium channel protein type 5 subunit alpha Ligand Dyclonine Superfamily
Class Class 298

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Histamine H3 receptor Ligand ABT-239 Family 8 20
Irdabisant family 49 53
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 3
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Histamine H3 receptor and Histamine H2 receptor ligand N-[(3S)... 16 5
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Histamine H3 receptor ligand SureCN2784769 family 12 2
Histamine H3 receptor ligand SureCN2785131 family 7 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
5-hydroxytryptamine receptor 3A ligand 5-[4-[3-(azepan-1-yl)pr... 2 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Histamine H3 receptor ligand SureCN7244264 family 1 0
Histamine H3 receptor ligand 3-[[(1S,4S)-5-[3-[4-(cyclopropane... 1 3
Thyroid hormone receptor beta ligand 3-(4-acetylpiperazin-1-yl... 3 2
oxybenzoate NP ZINC04029407 Family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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