CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10559
Family Name NS3 and Neutrophil elastase inhibitor (2S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[1-cyclopropyl-4-[[2-[[(1S)-2-(dimethylamino)-2-oxo-1-phenylethyl]amino]-2-oxoethyl]amino]-3,4-dioxobutan-2-yl]-3-azabicyclo[2.2.1]heptane-2-carboxamide family
No. of Seeds 1 No. of Other Members 3
Family Centroid CFAMM00402832 Functional Category Bioactive
Superfamily NS3 and Neutrophil elastase Binder Superfamily
Class Class 1043

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Prothrombin Inhibitor Ppack Family 5 4
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(2-phenylethy... 7 9
Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7
Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7
NS3 inhibitor SureCN14450642 family 4 7
NS3 inhibitor 2-methylpropyl N-[(2S)-1-[(3aR,4S,6aR)-4-[[1-[[2... 1 0
Cationic trypsin and Prothrombin inhibitor (3S,6S)-6-amino-6-b... 4 2
Genome polyprotein inhibitor Benzoyl-KKR-H family 1 1


External ID

Functional Category

Molecule Name

CFAMM00402832 CHEMBL203723 Bioactive (2S)-3-[(2S)-2-(tert-butylcarbamoylamino)-3,3-dimethylbutanoyl]-N-[1-cyclopropyl-4-[[2-[[(1S)-2-(dimethylamino)-2-oxo-1-phenylethyl]amino]-2-oxoethyl]amino]-3,4-dioxobutan-2-yl]-3-azabicyclo[2.2.1]heptane-2-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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