CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10577
Family Name Substance-P receptor and Potassium voltage-gated channel subfamily H member 2 ligand AGN-PC-075ZX5 family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00402962 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 1A and Substance-P receptor Binder Superfamily
Class Class 67

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Equilibrative nucleoside transporter 1 inhibitor Draflazine fa... 1 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Substance-P receptor and Potassium voltage-gated channel subfa... 4 7
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN13655018... 6 23
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor ligand AGN-PC-073QYE family 6 11
Melanin-concentrating hormone receptor 1 ligand AGN-PC-0762XZ ... 3 1
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Transient receptor potential cation channel subfamily V member... 1 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00402960 CHEMBL380408 Bioactive AGN-PC-075ZY2
CFAMM00402964 CHEMBL381984 Bioactive 4-[4-[3-[3,5-bis(trifluoromethyl)phenyl]-3-methyl-2-oxopyrrolidin-1-yl]-4-phenylcyclohexyl]-1-(2-chlorophenyl)piperazin-2-one
CFAMM00402963 CHEMBL383048 Bioactive 4-[4-[3-[3,5-bis(trifluoromethyl)phenyl]-3-methyl-2-oxopyrrolidin-1-yl]-4-phenylcyclohexyl]-1-phenylpiperazin-2-one
CFAMM00402962 CHEMBL203961 Bioactive AGN-PC-075ZX5
CFAMM00402961 CHEMBL380651 Bioactive 4-[4-[3-[3,5-bis(trifluoromethyl)phenyl]-2-oxopiperidin-1-yl]-4-phenylcyclohexyl]-1-phenylpiperazin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

38798 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543