CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10581
Family Name Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid family
No. of Seeds 15 No. of Other Members 14
Family Centroid CFAMM00403001 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Egl nine homolog 1 Binder Superfamily
Class Class 1253

Cousin Family NamesSeedsMembers
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Type-1 angiotensin II receptor Ligand Eprosartan Family 36 176
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Translocator protein Inhibitor Emapunil Family 7 89
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Casein kinase II subunit alpha Inhibitor CX-4945 Family 1 7
Class II cytokine receptor Ligand IL-10 Family 7 45
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 7 3
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
Cholecystokinin receptor type A ligand AGN-PC-0A9S2C family 4 8
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Neuropeptide Y receptor type 5 ligand AGN-PC-07R6YQ family 7 7
Neuropeptide Y receptor type 5 ligand SureCN4170426 family 4 13
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 1 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-[4-(2,4-... 2 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 4-[4-[1-(6... 3 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 7 5
Egl nine homolog 1 and Egl nine homolog 2 inhibitor 1-(6-metho... 4 2
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 4-[4-[1-(6... 5 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 4-[4-[1-(6... 10 0
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 2 0
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Coagulation factor VII inhibitor 2-[2-[(1-aminoisoquinolin-6-y... 1 14
Coagulation factor VII and Coagulation factor X inhibitor Ono ... 2 4
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 6
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
Type-1 angiotensin II receptor ligand 2-ethyl-4-[[4-[2-(2H-tet... 2 0
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Serine/threonine-protein kinase mTOR inhibitor 3-(cyclohexylme... 2 1


External ID

Functional Category

Molecule Name

CFAMM00402988 CHEMBL2041182 Bioactive 3-methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-1-(6-methylpyrimidin-4-yl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
CFAMM00403001 CHEMBL2041193 Bioactive 3-methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
CFAMM00402987 CHEMBL2041185 Bioactive 4-[4-[1-(3-methoxypyrazin-2-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]-3-methylbenzoic acid
CFAMM00403000 CHEMBL2041190 Bioactive 3-methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
CFAMM00402986 CHEMBL2041184 Bioactive 3-methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-1-(2-methylpyrimidin-4-yl)-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
CFAMM00402999 CHEMBL2041191 Bioactive 3-methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acid
CFAMM00402985 CHEMBL2041187 Bioactive 4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
CFAMM00402998 CHEMBL2041194 Bioactive 3-methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acid
CFAMM00402984 CHEMBL2041186 Bioactive 3-methyl-4-[4-[1-(3-methylpyrazin-2-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
CFAMM00402977 CHEMBL2040854 Bioactive 3-methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-(4-oxo-1H-pyrimidin-6-yl)-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acid
CFAMM00402983 CHEMBL2041189 Bioactive 4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
CFAMM00402989 CHEMBL2041183 Bioactive 3-methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-[6-(trifluoromethyl)pyrimidin-4-yl]-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
CFAMM00403002 CHEMBL2041192 Bioactive 4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-4-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
CFAMM00402982 CHEMBL2041188 Bioactive 3-methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid
CFAMM00402995 CHEMBL2043011 Bioactive 4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-(4-oxo-1H-pyrimidin-6-yl)-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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National University of Singapore, Singapore

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