CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10604
Family Name Cathepsin K and Cathepsin L1 inhibitor (2S)-2-[[(1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl]amino]-N-(cyanomethyl)-4-methylpentanamide family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00403130 Functional Category Bioactive
Superfamily Papain and Cathepsin K Binder Superfamily
Class Class 3621

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Cathepsin K and Cathepsin S inhibitor 1-benzyl-3-[(2S)-1-[[cya... 1 0
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
Cathepsin S and Cathepsin K inhibitor SureCN3476615 family 4 1
Baculoviral IAP repeat-containing protein 2 inhibitor (2S)-N-[... 1 0
Papain and Cathepsin S inhibitor dipeptide-derived nitrile, 28... 1 2


External ID

Functional Category

Molecule Name

CFAMM00403130 CHEMBL204277 Bioactive (2S)-2-[[(1S)-1-(4-bromophenyl)-2,2,2-trifluoroethyl]amino]-N-(cyanomethyl)-4-methylpentanamide
CFAMM00403135 CHEMBL372979 Bioactive (2S)-2-[[1-(4-bromophenyl)-2,2,2-trifluoroethyl]amino]-N-(cyanomethyl)-4-methylpentanamide
CFAMM00403134 CHEMBL372046 Bioactive (2S)-2-[[1-(4-bromophenyl)-2,2,3,3,3-pentafluoropropyl]amino]-N-(cyanomethyl)-4-methylpentanamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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