CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10609
Family Name Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenylphenyl)-2,8-diazaspiro[4.5]decan-8-yl]methyl]pyridin-3-yl]acetic acid family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00403208 Functional Category Bioactive
Superfamily Sodium channel protein type 5 subunit alpha Ligand Disopyramide Superfamily
Class Class 295

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Histamine H1 receptor Ligand (s)-(+)-dimethindene Maleate Family 6 12
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
Substance-P receptor Ligand GSK424887 Family 8 184
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Setipiprant family 5 118
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Transient receptor potential cation channel subfamily V member... 6 23
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
Egl nine homolog 2 Inhibitor Pyridine-2,4-dicarboxylic Acid Fa... 2 21
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 22
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
Melanocortin receptor 4 and Potassium voltage-gated channel su... 2 12
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
NS5B protein inhibitor AC1NQMYG family 6 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
C-C chemokine receptor type 5 ligand AC1LA259 family 1 1
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 4 7
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 20 37
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 5 2
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor AG... 1 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
NS5B protein inhibitor AC1O5AET family 3 1
NS5B protein inhibitor AC1NQMYP family 5 0
Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... 2 10
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
5-hydroxytryptamine receptor 4 ligand 4-[2-[4-[[(1-propan-2-yl... 1 1
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 3
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Phospholipase A2, membrane associated inhibitor AGN-PC-075RBK ... 1 2
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 1 2
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Glutamate carboxypeptidase 2 inhibitor 1-[(3-carboxyphenyl)met... 4 11
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 0
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0
Transmembrane prolyl 4-hydroxylase inhibitor 2,2'-Bipyridine-5... 1 1
Putative NP ZINC15919780 Family 2 0
2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-2-ium-8-carboxylate N... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403209 CHEMBL2443222 Bioactive 3-[5-methyl-6-[[1-oxo-2-(4-phenylphenyl)-2,8-diazaspiro[4.5]decan-8-yl]methyl]pyridin-3-yl]propanoic acid
CFAMM00403208 CHEMBL2443221 Bioactive 2-[5-methyl-6-[[1-oxo-2-(4-phenylphenyl)-2,8-diazaspiro[4.5]decan-8-yl]methyl]pyridin-3-yl]acetic acid
CFAMM00403205 CHEMBL2443114 Bioactive 4-[4-[8-[(3-methylpyridin-2-yl)methyl]-1-oxo-2,8-diazaspiro[4.5]decan-2-yl]phenyl]benzoic acid
CFAMM00403210 CHEMBL2042993 Bioactive 1'-[(3-methylpyridin-2-yl)methyl]-2-oxo-1-(4-phenylphenyl)spiro[indole-3,4'-piperidine]-5-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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