CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10610
Family Name Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-methylpyridin-2-yl)methyl]-3-(4-phenylphenyl)-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decane-2,4-dione family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00156553 Functional Category Bioactive
Superfamily Egl nine homolog 1 and Egl nine homolog 2 Binder Superfamily
Class Class 4519

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Transient receptor potential cation channel subfamily V member... 15 457
Neuromedin-K receptor Ligand SB222200 Family 17 235
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Substance-P receptor Ligand TAK-637 Family 18 63
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
GDC-0349 family 44 77
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Class II cytokine receptor Ligand IL-10 Family 7 45
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5856722 family 3 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 0
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 7 5
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 4-[4-[1-(6... 5 0
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 2 0
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Renin inhibitor AGN-PC-073MLF family 7 6
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Translocator protein inhibitor CHEMBL2331870 family 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Transient receptor potential cation channel subfamily V member... 1 0
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-meth... 1 0
Melanin-concentrating hormone receptor 1 ligand 1-[(2-fluoroph... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403211 CHEMBL2042995 Bioactive 1-[(3-methylpyridin-2-yl)methyl]-1'-(4-phenylphenyl)spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridine]-2'-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26379 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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