CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10616
Family Name Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00403240 Functional Category Bioactive
Superfamily Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) Benzimidazole-4-carboxamide Superfamily
Class Class 1456

Cousin Family NamesSeedsMembers
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Thyroid hormone receptor beta ligand CHEMBL1325165 family 1 6
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 4
NS5B protein inhibitor (2E)-1-cyclohexyl-2-(2-fluoro-4-oxocycl... 2 10
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Plasma kallikrein and Coagulation factor VII inhibitor 2-[(3E)... 15 49
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 1 6
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Histamine H1 receptor and Substance-P receptor ligand AGN-PC-0... 10 6
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Smoothened homolog and Sonic hedgehog protein inhibitor 496794... 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Smoothened homolog inhibitor N-[amino-[3-(1H-indol-2-yl)anilin... 1 4
Tryptase alpha/beta-1 and Tryptase delta inhibitor AGN-PC-0763... 1 1
Mitogen-activated protein kinase 14 inhibitor N-[4-methyl-3-[(... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403240 CHEMBL2043430 Bioactive N-[3-(1H-benzimidazol-2-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide
CFAMM00403239 CHEMBL472997 Bioactive SureCN14615301

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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