CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10619
Family Name B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[[5-(piperazine-1-carbonyl)pyridin-2-yl]amino]methyl]phenyl]benzoate family
No. of Seeds 22 No. of Other Members 11
Family Centroid CFAMM00403291 Functional Category Bioactive
Superfamily B1 bradykinin receptor and Protease Binder Superfamily
Class Class 1253

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Smoothened homolog Inhibitor LDE225 Family 3 76
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 22
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
B1 bradykinin receptor ligand AGN-PC-00CTAF family 1 3
Neuropeptide Y receptor type 5 ligand AGN-PC-07R6YQ family 7 7
Neuropeptide Y receptor type 5 ligand SureCN4170426 family 4 13
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Coagulation factor VII inhibitor 2-[2-[(1-aminoisoquinolin-6-y... 1 14
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Integrin beta-1 and Integrin alpha-5 inhibitor SureCN14453385 ... 5 0
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Neuropeptide Y receptor type 5 ligand SureCN5430956 family 11 1
Neutrophil elastase inhibitor AGN-PC-076VCN family 3 25
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Neuropeptide Y receptor type 5 ligand AGN-PC-07CRFU family 18 0
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2
P2Y purinoceptor 12 inhibitor SureCN3928692 family 5 0
P2Y purinoceptor 12 inhibitor SureCN3923520 family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403263 CHEMBL208248 Bioactive methyl 2-fluoro-6-[3-fluoro-4-[[[5-(piperidin-1-ylmethyl)pyridin-2-yl]amino]methyl]phenyl]benzoate
CFAMM00403276 CHEMBL207377 Bioactive AGN-PC-0761RY
CFAMM00403269 CHEMBL208241 Bioactive methyl 2-fluoro-6-[3-fluoro-4-[[[5-(4-prop-2-enylpiperazine-1-carbonyl)pyridin-2-yl]amino]methyl]phenyl]benzoate
CFAMM00403282 CHEMBL382228 Bioactive AGN-PC-0761SE
CFAMM00403275 CHEMBL424868 Bioactive methyl 2-fluoro-6-[3-fluoro-4-[[[5-(4-pyridin-3-ylpiperazine-1-carbonyl)pyridin-2-yl]amino]methyl]phenyl]benzoate
CFAMM00403268 CHEMBL208006 Bioactive AGN-PC-0761ZH
CFAMM00403281 CHEMBL425588 Bioactive AGN-PC-00CTRB
CFAMM00403274 CHEMBL207378 Bioactive methyl 2-fluoro-6-[3-fluoro-4-[[[5-(4-propylpiperazine-1-carbonyl)pyridin-2-yl]amino]methyl]phenyl]benzoate
CFAMM00403280 CHEMBL437704 Bioactive methyl 2-fluoro-6-[3-fluoro-4-[[[5-(4-propan-2-ylpiperazine-1-carbonyl)pyridin-2-yl]amino]methyl]phenyl]benzoate
CFAMM00403273 CHEMBL381974 Bioactive AGN-PC-0761TB
CFAMM00403260 CHEMBL207800 Bioactive methyl 2-[4-[[[5-[4-[(E)-but-2-enyl]piperazine-1-carbonyl]pyridin-2-yl]amino]methyl]-3-fluorophenyl]-6-fluorobenzoate
CFAMM00403286 CHEMBL380920 Bioactive methyl 2-[4-[[[5-(4-cyclohexylpiperazine-1-carbonyl)pyridin-2-yl]amino]methyl]-3-fluorophenyl]-6-fluorobenzoate
CFAMM00403266 CHEMBL204562 Bioactive AGN-PC-0761ZQ
CFAMM00403259 CHEMBL204356 Bioactive AGN-PC-0761ZV
CFAMM00403285 CHEMBL207937 Bioactive AGN-PC-00S3UI
CFAMM00403265 CHEMBL208991 Bioactive methyl 2-[4-[[[5-(4-butan-2-ylpiperazine-1-carbonyl)pyridin-2-yl]amino]methyl]-3-fluorophenyl]-6-fluorobenzoate
CFAMM00403278 CHEMBL207913 Bioactive methyl 2-fluoro-6-[3-fluoro-4-[[[5-[4-(3-methylbutyl)piperazine-1-carbonyl]pyridin-2-yl]amino]methyl]phenyl]benzoate
CFAMM00403291 CHEMBL207122 Bioactive methyl 2-fluoro-6-[3-fluoro-4-[[[5-(piperazine-1-carbonyl)pyridin-2-yl]amino]methyl]phenyl]benzoate
CFAMM00403284 CHEMBL206519 Bioactive methyl 2-[4-[[[5-[4-(cyclobutylmethyl)piperazine-1-carbonyl]pyridin-2-yl]amino]methyl]-3-fluorophenyl]-6-fluorobenzoate
CFAMM00403264 CHEMBL380679 Bioactive methyl 2-[4-[[[5-[4-(cyclopentylmethyl)piperazine-1-carbonyl]pyridin-2-yl]amino]methyl]-3-fluorophenyl]-6-fluorobenzoate
CFAMM00403270 CHEMBL208320 Bioactive methyl 2-[4-[[[5-(4-butylpiperazine-1-carbonyl)pyridin-2-yl]amino]methyl]-3-fluorophenyl]-6-fluorobenzoate
CFAMM00403283 CHEMBL207022 Bioactive methyl 2-[4-[[[5-[4-(cyclopropylmethyl)piperazine-1-carbonyl]pyridin-2-yl]amino]methyl]-3-fluorophenyl]-6-fluorobenzoate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26831 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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