CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10620
Family Name Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(3-hydroxypentan-3-yl)phenoxy]methyl]-4-(furan-3-yl)chromen-2-one family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00403293 Functional Category Bioactive with Natural Product
Superfamily Arachidonate 5-lipoxygenase and Thyroid hormone receptor beta Binder Superfamily
Class Class 197

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
DNA Binder Methoxsalen Family 10 1638
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Arachidonate 5-lipoxygenase Inhibitor L-702-539 Family 1 4
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Prostaglandin G/H synthase 2 Inhibitor Neolignan 9-nor-7,8-deh... 1 7
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
ELAV-like protein 1 and Myosin light chain kinase, smooth musc... 1 32
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Carbonic anhydrase 2 inhibitor (2-sulfamoyl-1-benzofuran-5-yl)... 4 2
Thromboxane A2 receptor and Prostacyclin receptor ligand AGN-P... 2 30
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-[(1S,3S,5... 2 0
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 78
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Prelamin-A/C and Inositol monophosphatase 1 inhibitor MLS00053... 1 1
Putative NP ZINC31165975 Family 4 0
NP 4-(7-methoxybenzofuran-2-yl)-2-oxo-7-phenyl-2h-chromen-6-yl... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403293 CHEMBL204365 Bioactive 7-[[3-fluoro-5-(3-hydroxypentan-3-yl)phenoxy]methyl]-4-(furan-3-yl)chromen-2-one
CFAMM00403302 CHEMBL207109 Bioactive 7-[[3-fluoro-5-[(1S,3S,5R)-3-hydroxy-6,8-dioxabicyclo[3.2.1]octan-3-yl]phenoxy]methyl]-4-(furan-3-yl)chromen-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27059 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543