Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Vasopressin V1a receptor Ligand Felypressin Family 12 820 Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443 Glutathione S-transferase Inhibitor Praziquantel Family 5 167 Prothrombin Inhibitor Efegatran Family 9 47 Neutrophil elastase Inhibitor FK-706 Family 8 85 Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348 Beta-secretase 1 Inhibitor MMI-175 Family 30 137 72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87 Plasmepsin-1 Inhibitor SC-5003 Family 93 173 Neuromedin-K receptor Ligand PD-157672 Family 9 37 Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77 Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28 Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47 Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5 Cathepsin K inhibitor [(3S)-4,4-dimethyl-1-(naphthalene-2-carb... 4 9 Cathepsin K inhibitor (4-phenylphenyl) (3S)-3-[[(3S)-1,2-dioxo... 4 10 Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(2-phenylethy... 7 9 Cathepsin K inhibitor [(3S)-4,4-dimethyl-2-oxo-1-(phenylcarbam... 3 1 Cathepsin K inhibitor [(3S)-1-(1-benzothiophene-2-carbonyl)-4,... 2 3 Cathepsin K inhibitor [(3S)-1-(benzenesulfonyl)-4,4-dimethylpy... 2 0 Cathepsin K inhibitor [(3R)-4,4-dimethyl-1-phenylpentan-3-yl] ... 7 7 Neutrophil elastase inhibitor benzyl N-[(2S)-1-[(2S)-2-[[(3S)-... 4 0 Chymase and Chymotrypsinogen A inhibitor tert-butyl N-[(2S)-1-... 2 7 Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 3 4 Cathepsin K and Cathepsin S inhibitor (2,2,4-trimethyl-3-bicyc... 1 0 Cathepsin K and Cathepsin S inhibitor SureCN6197793 family 1 0 NS3 and Neutrophil elastase inhibitor (2S)-3-[(2S)-2-(tert-but... 1 3 NS3 inhibitor 2-methylpropyl N-[(2S)-1-[(3aR,4S,6aR)-4-[[1-[[2... 1 0 Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1 Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0 Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0 Trypsin-1 and Prothrombin inhibitor tert-butyl N-[2-[(2S)-2-[[... 1 0 NS3 inhibitor tert-butyl N-[(1S)-1-cyclohexyl-2-[(1R,2S,5S)-2-... 1 0 NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0 Putative NP ZINC08790318 Family 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00403322 CHEMBL386588 Bioactive
tert-butyl N-[(1S)-2-[(1R,2S,5S)-2-[(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)carbamoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,3-dihydro-1H-inden-2-yl)-2-oxoethyl]carbamate CFAMM00403328 CHEMBL366077 Bioactive
SureCN12012829 CFAMM00403326 CHEMBL361002 Bioactive
[(5S)-5-[[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]carbamoyl]-1-[(2S)-2-[[(2S)-2-[(6-methoxy-6-oxohexanoyl)amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]pyrrolidin-3-yl] 3,4-dihydro-1H-isoquinoline-2-carboxylate CFAMM00403323 CHEMBL379085 Bioactive
2-methylpropyl N-[(2S)-1-[(2S,4R)-4-tert-butylsulfanyl-2-[[1-[[2-[[(1S)-2-(dimethylamino)-2-oxo-1-phenylethyl]amino]-2-oxoethyl]amino]-1,2-dioxohexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate CFAMM00403327 CHEMBL378158 Bioactive
2-methylpropyl N-[(1S)-1-cyclohexyl-2-[(8S)-8-[[1-[[2-[[(1S)-2-(dimethylamino)-2-oxo-1-phenylethyl]amino]-2-oxoethyl]amino]-1,2-dioxohexan-3-yl]carbamoyl]-1,4-dithia-7-azaspiro[4.4]nonan-7-yl]-2-oxoethyl]carbamate CFAMM00403332 CHEMBL208305 Bioactive
2-methylpropyl N-[(1S)-1-cyclohexyl-2-[(3S)-3-[[1-[[2-[[(1S)-2-(dimethylamino)-2-oxo-1-phenylethyl]amino]-2-oxoethyl]amino]-1,2-dioxohexan-3-yl]carbamoyl]-6,10-dithia-2-azaspiro[4.5]decan-2-yl]-2-oxoethyl]carbamate CFAMM00403331 CHEMBL436923 Bioactive
SureCN14583436
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
