Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Histamine H1 receptor Ligand Astemizole Family 7 240 Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 13 Serine/threonine-protein kinase mTOR Inhibitor AZD8055 Family 2 2 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270 JNJ-39439335 family 5 11 DNA Binder Bisbenzimide (hoechst 33258) Family 4 159 Tyrosine kinase Inhibitor PKI166 Family 17 198 Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12 Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69 Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23 Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8 Serine/threonine-protein kinase mTOR Inhibitor (4-(6-morpholin... 2 11 Reverse transcriptase Inhibitor UK-129485 Family 23 221 cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83 Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11 Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1 cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10 Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11 Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6 Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5 Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7 D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4 Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2 Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11 Methionine--tRNA ligase, cytoplasmic and Methionine--tRNA liga... 8 6 Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9 cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4 Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5 Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17 Insulin-like growth factor 1 receptor ligand 3qqu family 2 12 Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 11 2 Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3 Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3 Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10 Methionine--tRNA ligase inhibitor 2-[3-[(6-ethyl-8-iodo-1,2,3,... 1 0 Poly [ADP-ribose] polymerase 1 inhibitor 4-[1-[3-(4-oxo-1H-qui... 1 3 Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7 Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 6 Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7 Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3 Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11 Plasma kallikrein and Coagulation factor VII inhibitor 2-[(3E)... 15 49 Coagulation factor VII inhibitor 2-[(3E)-3-(5-carbamimidoyl-1,... 3 1 Vascular endothelial growth factor receptor 2 and Vascular end... 4 2 Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0 Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1 Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1... 3 2 Serine/threonine-protein kinase Chk1 inhibitor 6-chloro-3-(1,3... 4 2 Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1 Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5 Protein kinase C theta type and Protein kinase C delta type in... 2 1 Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8 Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10 Vascular endothelial growth factor receptor 2 and Vascular end... 1 1 Purine nucleoside phosphorylase inhibitor SureCN6345422 family 9 11 Thymidylate synthase inhibitor 3-(methylamino)-5,6-dihydro-4H-... 2 19 Adenosine receptor A1 and Adenosine receptor A2a ligand 7-meth... 2 0 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0 Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3 G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1 cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6 Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0 Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0 Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6 Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 inhibi... 9 4 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00403358 CHEMBL205108 Bioactive
4-amino-3-(6-morpholin-4-yl-1H-benzimidazol-2-yl)-1H-1,7-naphthyridin-2-one CFAMM00403338 CHEMBL1650093 Bioactive
(6E)-6-[6-(3-hydroxypropyl)-4-[[(3S)-pyrrolidin-3-yl]amino]-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one CFAMM00403352 CHEMBL107709 Bioactive
SureCN12750407 CFAMM00403342 CHEMBL377609 Bioactive
4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-3-(1,3-dihydrobenzimidazol-2-ylidene)-8-methylquinolin-2-one CFAMM00403341 CHEMBL108106 Bioactive
2-[2-(diethylamino)ethylamino]-5H-benzo[c][1,5]naphthyridin-6-one CFAMM00403345 CHEMBL2152773 Bioactive
[2-(5-fluoro-1H-indol-4-yl)-4-morpholin-4-ylpyrido[3,2-d]pyrimidin-6-yl]methanol CFAMM00403353 CHEMBL1160877 Bioactive
2-[(1R,4R)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-5H-benzo[c][1,5]naphthyridin-6-one;2,2,2-trifluoroacetic acid CFAMM00403349 CHEMBL381283 Bioactive
(3Z)-4-amino-3-(5-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)-1,6-naphthyridin-2-one CFAMM00403348 CHEMBL543394 Bioactive
2-(4-pyrrolidin-1-ylpiperidin-1-yl)-5H-benzo[c][1,5]naphthyridin-6-one;hydrochloride CFAMM00403355 CHEMBL107284 Bioactive
methanesulfonic acid;2-piperazin-1-yl-5H-benzo[c][1,5]naphthyridin-6-one CFAMM00403346 CHEMBL209256 Bioactive
4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-5,6-dichloro-3-(1,3-dihydrobenzimidazol-2-ylidene)quinolin-2-one
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Chen Yuzong Deputy
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