CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10635
Family Name Renin inhibitor 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-6-[4-[2-(3-methoxypropoxy)phenyl]-2,2-dimethyl-5-oxopiperazin-1-yl]-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid family
No. of Seeds 5 No. of Other Members 9
Family Centroid CFAMM00403417 Functional Category Bioactive with Natural Product
Superfamily Beta-1 adrenergic receptor Ligand Practolol Superfamily
Class Class 516

Cousin Family NamesSeedsMembers
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Renin inhibitor (2S,4S,5S)-5-amino-N-butyl-6-[4-(2-chloropheny... 30 3
Renin inhibitor (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-o... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Renin inhibitor (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor 2-[(3S)... 5 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403414 CHEMBL2048566 Bioactive (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-6-[4-[2-(2-methoxyethoxy)phenyl]-2,2-dimethyl-5-oxopiperazin-1-yl]-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403413 CHEMBL2048567 Bioactive (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-6-[4-(2-methoxyphenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403417 CHEMBL2048563 Bioactive 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-6-[4-[2-(3-methoxypropoxy)phenyl]-2,2-dimethyl-5-oxopiperazin-1-yl]-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403410 CHEMBL2046465 Bioactive (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-6-[4-[2-(methoxymethoxy)phenyl]-2,2-dimethyl-5-oxopiperazin-1-yl]-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403416 CHEMBL2048564 Bioactive (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-6-[4-[2-(3-methoxypropoxy)phenyl]-2,2-dimethyl-5-oxopiperazin-1-yl]-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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