CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10637
Family Name Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6-[(3S)-3-phenylpiperazin-1-yl]pyridin-2-yl]methanone family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00403425 Functional Category Bioactive
Superfamily Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6-[(3S)-3-phenylpiperazin-1-yl]pyridin-2-yl]methanone Superfamily
Class Class 4797

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Delavirdine Family 1 68
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Prothrombin Inhibitor Dabigatran Family 7 182
Transient receptor potential cation channel subfamily V member... 16 295
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Substance-P receptor Ligand TAK-637 Family 18 63
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 2 3
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN14726714... 4 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 5 0
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Collagenase 3 inhibitor MMP-13 Inhibitor family 1 1
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0
Amine oxidase [flavin-containing] B and Metabotropic glutamate... 2 0
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2
Acetylcholinesterase inhibitor 11-amino-3,3-dimethyl-12-phenyl... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403425 CHEMBL2046642 Bioactive (2-aminopyridin-3-yl)-[6-[(3S)-3-phenylpiperazin-1-yl]pyridin-2-yl]methanone
CFAMM00403424 CHEMBL2046649 Bioactive (2-aminopyridin-3-yl)-[6-[(3S)-3-(2-methylpropyl)piperazin-1-yl]-3-phenylpyridin-2-yl]methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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