CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10668
Family Name Dual specificity protein kinase TTK inhibitor 4-[[2-(2-methyl-4-morpholin-4-ylanilino)-7H-purin-6-yl]amino]cyclohexan-1-ol family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00403555 Functional Category Bioactive
Superfamily Cyclin-dependent kinase 2 Inhibitor Seliciclib Superfamily
Class Class 920

Cousin Family NamesSeedsMembers
Toll-like receptor 7 Ligand Imiquimod Family 3 237
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Cyclin-dependent kinase 2 Inhibitor 2-anilino-6-cyclohexylmeth... 4 13
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Methylated-DNA--protein-cysteine methyltransferase Inhibitor 6... 4 5
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 6 24
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Adenosine deaminase inhibitor AGN-PC-00FYYU family 4 5
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Transient receptor potential cation channel subfamily V member... 4 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Adenosine receptor A3 ligand (2R,3R,4S)-2-[2-chloro-6-[(3-fluo... 6 7
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403555 CHEMBL2047951 Bioactive 4-[[2-(2-methyl-4-morpholin-4-ylanilino)-7H-purin-6-yl]amino]cyclohexan-1-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543