CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10682
Family Name Renin inhibitor (2S,4S,5S)-5-amino-N-butyl-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid family
No. of Seeds 30 No. of Other Members 3
Family Centroid CFAMM00403745 Functional Category Bioactive
Superfamily Renin Binder Superfamily 8
Class Class 348

Cousin Family NamesSeedsMembers
Renin inhibitor SureCN9038274 family 3 8
Renin inhibitor 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4... 5 9
Renin inhibitor (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-o... 9 10
Renin inhibitor (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-o... 2 0
Renin inhibitor (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 8 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
Renin inhibitor (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 1 0
Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(5-fluoro-2-methylphen... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403743 CHEMBL2048706 Bioactive (2S,4S,5S)-5-amino-6-[4-(2-chloro-5-fluorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-N-[(2S)-2-methylbutyl]-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403736 CHEMBL2387447 Bioactive (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(2,2-dimethylpropyl)-2-ethyl-4-hydroxyhexanamide;(E)-but-2-enedioic acid
CFAMM00403725 CHEMBL2387553 Bioactive (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-2-ethyl-4-hydroxy-N-(4-methylphenyl)hexanamide;(E)-but-2-enedioic acid
CFAMM00403742 CHEMBL2048707 Bioactive (2S,4S,5S)-5-amino-6-[4-(2-chloro-5-fluorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-cyclohexyl-4-hydroxy-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403735 CHEMBL2387446 Bioactive (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(2,2-dimethylpropyl)-4-hydroxy-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403724 CHEMBL2387552 Bioactive (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-2-ethyl-N-(4-fluorophenyl)-4-hydroxyhexanamide;(E)-but-2-enedioic acid
CFAMM00403730 CHEMBL2048571 Bioactive (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403741 CHEMBL2387546 Bioactive (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-N-phenyl-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403734 CHEMBL2387444 Bioactive (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-N-(2-methylpropyl)-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403723 CHEMBL2387452 Bioactive (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-N-(3-hydroxy-2,2-dimethylpropyl)-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403740 CHEMBL2387544 Bioactive (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-N-(4-hydroxycyclohexyl)-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403733 CHEMBL2387564 Bioactive (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-2-ethyl-4-hydroxy-N-[[1-(hydroxymethyl)cyclopentyl]methyl]hexanamide;(E)-but-2-enedioic acid
CFAMM00403722 CHEMBL2387453 Bioactive (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-2-ethyl-4-hydroxy-N-(3-hydroxy-2,2-dimethylpropyl)hexanamide;(E)-but-2-enedioic acid
CFAMM00403739 CHEMBL2387545 Bioactive (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-N-(oxan-4-yl)-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403728 CHEMBL2387563 Bioactive (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-2-ethyl-N-[2-ethyl-2-(hydroxymethyl)butyl]-4-hydroxyhexanamide;(E)-but-2-enedioic acid
CFAMM00403732 CHEMBL2387565 Bioactive (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-2-ethyl-4-hydroxy-N-[[1-(hydroxymethyl)cyclohexyl]methyl]hexanamide;(E)-but-2-enedioic acid
CFAMM00403745 CHEMBL2048702 Bioactive (2S,4S,5S)-5-amino-N-butyl-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403731 CHEMBL2048579 Bioactive (2S,4S,5S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-6-[4-(2-chloro-5-fluorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403744 CHEMBL2048703 Bioactive (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-4-hydroxy-N-[(2S)-2-methylbutyl]-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403726 CHEMBL2387551 Bioactive (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(4-fluorophenyl)-4-hydroxy-2-propan-2-ylhexanamide;(E)-but-2-enedioic acid
CFAMM00403737 CHEMBL2387448 Bioactive (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(2,2-dimethylpropyl)-4-hydroxy-2-methylhexanamide;(E)-but-2-enedioic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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