CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10693
Family Name Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfonylamino)phenyl]ethyl]-2-thiophen-3-yl-1H-imidazo[4,5-b]pyridine-7-carboxamide family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00403773 Functional Category Bioactive
Superfamily Glycogen synthase kinase-3 beta and Nicotinamide phosphoribosyltransferase Binder Superfamily
Class Class 853

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Indiplon Family 4 25
Prothrombin Inhibitor Dabigatran Family 7 182
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 37 57
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Aurora kinase A and Aurora kinase B inhibitor 4-amino-N-[4-(th... 1 1
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Coagulation factor X inhibitor SureCN8290907 family 2 2
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Cyclin-dependent kinase 2 inhibitor aminoimidazo[1,2-a]pyridin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403775 CHEMBL2048672 Bioactive N-[2-[4-(dimethylsulfamoylamino)phenyl]ethyl]-2-thiophen-3-yl-1H-imidazo[4,5-b]pyridine-7-carboxamide
CFAMM00403773 CHEMBL2048662 Bioactive N-[2-[4-(ethylsulfonylamino)phenyl]ethyl]-2-thiophen-3-yl-1H-imidazo[4,5-b]pyridine-7-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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