CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1070
Family Name 5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine receptor 3B ligand 145970-12-3 family
No. of Seeds 3 No. of Other Members 28
Family Centroid CFAMM00318985 Functional Category Bioactive
Superfamily Androgen receptor and Histone deacetylase Binder Superfamily
Class Class 456

Cousin Family NamesSeedsMembers
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Neuromedin-K receptor Ligand Talnetant Family 3 49
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Retinoic acid receptor alpha Ligand LG100268 Family 2 33
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Phospholipase A2 Inhibitor Hyrtiosulawesine Family 1 3
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Vascular endothelial growth factor receptor 2 ligand indolyl q... 4 3
Renin inhibitor SureCN1144364 family 3 15
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Vascular endothelial growth factor receptor 2 ligand AGN-PC-05... 2 2
Vascular endothelial growth factor receptor 2 ligand 5-bromo-2... 1 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 1
Rho-associated protein kinase 2 and Rho-associated protein kin... 1 3
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 7 0
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... 3 13
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 2
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 1 3
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 1 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-08866Z fa... 2 0
Lutropin-choriogonadotropic hormone receptor ligand 5-[2-(4-te... 1 1
ATP-sensitive inward rectifier potassium channel 11 ligand N-[... 1 1
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00318963 CHEMBL113045 Bioactive 2-methyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-4-oxo-1H-quinoline-3-carboxamide
CFAMM00318985 CHEMBL109955 Bioactive 145970-12-3
CFAMM00318996 CHEMBL160714 Bioactive SureCN7435902

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22646 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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