CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10702
Family Name Receptor tyrosine-protein kinase erbB-2 and Epidermal growth factor receptor ligand 2-[4-[3-chloro-4-(1-methylindazol-4-yl)oxyanilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethanol family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00152742 Functional Category Bioactive
Superfamily Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Superfamily
Class Class 1049

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Varlitinib family 2 8
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Hepatocyte growth factor receptor ligand [3,5-dichloro-4-[4-(3... 1 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 3
Acyl-CoA desaturase 1 inhibitor 3-[4-(2-chlorophenoxy)piperidi... 1 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Glucagon receptor ligand SureCN2647807 family 3 7
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 0
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
Fibroblast growth factor receptor 1 and Proto-oncogene tyrosin... 2 0
Beta-secretase 1 and Amyloid beta A4 protein inhibitor SureCN3... 1 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403807 CHEMBL2048903 Bioactive 2-[4-[3-chloro-4-(1H-indazol-4-yloxy)anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethanol
CFAMM00403808 CHEMBL2048797 Bioactive 2-[4-[3-chloro-4-(1H-indol-4-yloxy)anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethanol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27276 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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