CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10712
Family Name Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-ethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)benzenesulfonamide family
No. of Seeds 7 No. of Other Members 8
Family Centroid CFAMM00389187 Functional Category Bioactive with Natural Product
Superfamily Histamine H3 receptor and Sodium-dependent serotonin transporter Binder Superfamily 3
Class Class 280

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Dapoxetine family 3 40
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
Neuropeptide Y receptor type 5 Ligand FR-230481 Family 2 17
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Tubulin beta chain Inhibitor Colchinol Family 3 109
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Neuropeptide Y receptor type 5 ligand AGN-PC-0750HA family 1 12
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
Matrix metalloproteinase-15 and Matrix metalloproteinase-16 in... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Muscarinic acetylcholine receptor M2 ligand (2R)-1-[(1S)-1-[4-... 10 2
Muscarinic acetylcholine receptor M2 ligand (2R)-4-cyclohexyl-... 12 0
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
Histamine H3 receptor ligand SureCN5093910 family 3 16
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 4 6
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 6-met... 2 6
Carbonic anhydrase 7 and Carbonic anhydrase 9 inhibitor 4-(6-e... 4 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 6-hydr... 1 5
Histamine H3 receptor ligand SureCN6071181 family 2 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 13 0
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Macrophage metalloelastase inhibitor 2-(2,5-dichlorophenyl)sul... 1 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Estrogen receptor and Estrogen receptor beta ligand SureCN6716... 2 0
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Neuropeptide Y receptor type 5 ligand N-[[4-[(2,3-dihydro-1,4-... 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-040NYF family 1 1
Benzazepines Metabolite N-Methylporphyroxine Family 1 2
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
2-[(1R,4aS,8aS)-4a-hydroxy-1-(4-methoxyphenyl)-2,3,4,5,6,7,8,8... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403860 CHEMBL2048935 Bioactive 6-propoxy-1-(4-sulfamoylphenyl)-3,4-dihydro-1H-isoquinoline-2-sulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26825 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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