CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10717
Family Name Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial and Kynurenine--oxoglutarate transaminase 3 inhibitor (3S)-3-amino-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2-one family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00403883 Functional Category Bioactive with Natural Product
Superfamily Disintegrin and Lethal factor Binder Superfamily
Class Class 1560

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand quinolone derivative Carteolol... 1 38
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 7
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Voltage-dependent L-type calcium channel Ligand Sq32,910 Family 1 25
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 2
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Neutrophil collagenase inhibitor (3R)-2-[4-[4-(dimethylamino)p... 2 4
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2R... 8 9
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(1-cyanocyclop... 4 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 3
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 2
Transient receptor potential cation channel subfamily V member... 2 7
Melanocortin receptor 4 ligand [4-[2-[(1S)-1-amino-3-methylbut... 1 0
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075HBO ... 2 44
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
(3R)-6,7-dimethoxy-1,2,3,4-tetrahydroquinoline-3-carboxylate N... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00403883 CHEMBL2049092 Bioactive (3S)-3-amino-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2-one
CFAMM00403888 CHEMBL2321943 Bioactive (3S)-3-amino-1-hydroxy-7-methoxy-6-phenoxy-3,4-dihydroquinolin-2-one
CFAMM00403887 CHEMBL2347110 Bioactive (3S)-3-amino-6-benzyl-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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