CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10720
Family Name Proteasome subunit beta type-5 inhibitor (2S)-N'-(2,2-dimethylpropyl)-N-[(2S)-3-hydroxy-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]butanediamide family
No. of Seeds 2 No. of Other Members 9
Family Centroid CFAMM00403918 Functional Category Bioactive with Natural Product
Superfamily Stromelysin-1 and Proteasome subunit beta type-5 Binder Superfamily
Class Class 3001

Cousin Family NamesSeedsMembers
Cathepsin K Inhibitor Odanacatib Family 33 84
Thymidylate synthase Inhibitor N-[tosyl-d-prolinyl]amino-ethan... 1 10
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Calpain Inhibitor SJA-6017 Family 2 12
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Bifunctional epoxide hydrolase 2 inhibitor N-cycloheptyl-1-(2,... 7 8
B1 bradykinin receptor ligand N-[(1R)-6-[(dimethylamino)methyl... 7 6
B1 bradykinin receptor ligand N-[(4R)-1,1-dioxo-3,4-dihydro-2H... 1 0
B1 bradykinin receptor ligand N-[(4S)-1-ethyl-3,3-dimethylpipe... 10 4
Neutrophil collagenase and Collagenase 3 inhibitor (2R)-2-[2-a... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 8 0


External ID

Functional Category

Molecule Name

CFAMM00403920 CHEMBL206001 Bioactive (2S)-N'-(2,2-dimethylpropyl)-N-[(2S)-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]butanediamide
CFAMM00403918 CHEMBL204946 Bioactive (2S)-N'-(2,2-dimethylpropyl)-N-[(2S)-3-hydroxy-1-[[(E,3S)-5-methyl-1-methylsulfonylhex-1-en-3-yl]amino]-1-oxopropan-2-yl]-2-[(4-methylphenyl)sulfonylamino]butanediamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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