CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10745
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4-[(5,5-dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]-N-propylacetamide family
No. of Seeds 5 No. of Other Members 5
Family Centroid CFAMM00404103 Functional Category Bioactive
Superfamily Prelamin-A/C and Inositol monophosphatase 1 Binder Superfamily 8
Class Class 3854

Cousin Family NamesSeedsMembers
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
GDC-0349 family 44 77
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Serine/threonine-protein kinase mTOR inhibitor SureCN2707225 f... 29 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 1 9
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Growth hormone secretagogue receptor type 1 ligand SureCN63605... 5 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Dihydrofolate reductase inhibitor WR 158122 family 1 0
Prostaglandin G/H synthase 2 inhibitor 6-ethoxy-2-(4-methylsul... 5 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1


External ID

Functional Category

Molecule Name

CFAMM00404103 CHEMBL2385755 Bioactive 2-[4-[(5,5-dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]-N-propylacetamide
CFAMM00404101 CHEMBL2385757 Bioactive 2-[4-[(5,5-dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]-N-(2-methylpropyl)acetamide
CFAMM00404100 CHEMBL2385759 Bioactive N-(2,2-dimethylpropyl)-2-[4-[(5,5-dioxo-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl]acetamide
CFAMM00404099 CHEMBL377514 Bioactive AGN-PC-008JZO
CFAMM00404098 CHEMBL205711 Bioactive AGN-PC-0760YT

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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