CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10747
Family Name Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimidin-4-yl)-2-cyanophenoxy]methyl]cyclohexane-1-carboxylic acid family
No. of Seeds 3 No. of Other Members 16
Family Centroid CFAMM00404142 Functional Category Bioactive
Superfamily SB1518 Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Leukotriene B4 receptor 1 ligand AGN-PC-07ZF09 family 3 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 6
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Sphingosine 1-phosphate receptor 1 ligand 4-[2-ethyl-3-[5-[4-p... 10 1
Sphingosine 1-phosphate receptor 1 ligand 4-[2-ethyl-3-[5-[6-p... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Transient receptor potential cation channel subfamily V member... 2 4
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 12
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 21
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[3,4-di... 2 0
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404142 CHEMBL2322163 Bioactive 4-[[4-(2-aminopyrimidin-4-yl)-2-cyanophenoxy]methyl]cyclohexane-1-carboxylic acid
CFAMM00404141 CHEMBL2322162 Bioactive methyl 4-[[4-(2-aminopyrimidin-4-yl)-2-cyanophenoxy]methyl]cyclohexane-1-carboxylate
CFAMM00404146 CHEMBL2057232 Bioactive 4-[3-[2-(3-cyano-4-propan-2-yloxyphenyl)pyrimidin-5-yl]-2-ethylphenyl]butanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26839 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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