CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10751
Family Name Smoothened homolog and Mitogen-activated protein kinase 14 inhibitor N-[2-methyl-5-(1,3,5-trimethylpyrazol-4-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00404186 Functional Category Bioactive
Superfamily Calcium-activated potassium channel subunit alpha-1 Ligand AVE0118 Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Family 13 41
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 50 36
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 5 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 4
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Translocator protein inhibitor AGN-PC-080ILF family 9 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 19 40
Histamine H3 receptor ligand SureCN2784306 family 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 3 15
Mitogen-activated protein kinase 14 inhibitor N-[4-methyl-3-[[... 2 2
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 1 1
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
Poly [ADP-ribose] polymerase 1 inhibitor 1-(4-methoxyphenyl)-3... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Coagulation factor X inhibitor AGN-PC-046RMQ family 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 2 3
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 25 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Diacylglycerol O-acyltransferase 1 inhibitor AGN-PC-07ZCRO family 1 2
Glucagon receptor ligand AGN-PC-0DAGZC family 3 12
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 3 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404186 CHEMBL2059870 Bioactive N-[2-methyl-5-(1,3,5-trimethylpyrazol-4-yl)phenyl]-4-(pyridin-2-ylmethoxy)benzamide
CFAMM00404185 CHEMBL2059871 Bioactive N-[2-methyl-5-[5-(trifluoromethyl)-1H-pyrazol-3-yl]phenyl]-4-(pyridin-2-ylmethoxy)benzamide
CFAMM00404184 CHEMBL2057336 Bioactive N-[5-(6-aminopyridazin-3-yl)-2-methylphenyl]-4-(pyridin-2-ylmethoxy)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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