Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580 PF-4217903 family 14 65 Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84 Vascular endothelial growth factor receptor 1 and Vascular end... 6 23 RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124 Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79 RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90 Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13 5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2 Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1 cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11 Platelet-activating factor receptor ligand SureCN9384429 family 11 3 Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27 Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1 Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27 Type-1B angiotensin II receptor ligand SureCN683399 family 3 0 Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9 Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14 Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1 Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1 5-hydroxytryptamine receptor 6 ligand 3-(benzenesulfonyl)-N,5-... 4 1 Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15 Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3 Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5 Calcitonin gene-related peptide type 1 receptor ligand SureCN2... 2 1 Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 2 3 Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4 Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14 Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11 Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4 Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0 Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1 Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11 Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3 Aurora kinase B and Vascular endothelial growth factor recepto... 1 2 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0 Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1 Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0 Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2 Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5 Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2 Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1 Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1 Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6 Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0 Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1 Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0 Tyrosine-protein kinase JAK2 inhibitor N,N-dimethyl-4-[[8-(4-m... 2 1 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1 Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13 RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7 RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0 Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0 TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0 Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1 Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00404191 CHEMBL2057371 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-(2-oxo-2-pyrrolidin-1-ylethyl)urea CFAMM00404204 CHEMBL2057368 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-[2-(5-cyclopropyltetrazol-2-yl)ethyl]urea CFAMM00404189 CHEMBL2057373 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]urea CFAMM00404188 CHEMBL2057372 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-(2-morpholin-4-yl-2-oxoethyl)urea CFAMM00404201 CHEMBL2057363 Bioactive
2-[[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]carbamoylamino]-N,N-dimethylacetamide CFAMM00404200 CHEMBL2057367 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-[2-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)ethyl]urea
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00404198 CHEMBL2057365 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-[2-(2-methyl-1,3-thiazol-4-yl)ethyl]urea CFAMM00404193 CHEMBL2059911 Bioactive
N-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]morpholine-4-carboxamide CFAMM00404197 CHEMBL2064570 Bioactive
N-[8-fluoro-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide CFAMM00404196 CHEMBL2064483 Bioactive
N-[6-(3-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide CFAMM00404194 CHEMBL2059912 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-[2-(dimethylamino)ethyl]urea CFAMM00404206 CHEMBL2064514 Bioactive
N-[8-methyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide CFAMM00404199 CHEMBL2057364 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-(2-pyrazol-1-ylethyl)urea CFAMM00404192 CHEMBL2059910 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-methylurea CFAMM00404205 CHEMBL2059907 Bioactive
N-[6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide CFAMM00404190 CHEMBL2057370 Bioactive
2-[[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]carbamoylamino]-N-methylacetamide CFAMM00404203 CHEMBL2057369 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-[3-(5-cyclopropyltetrazol-2-yl)propyl]urea CFAMM00404202 CHEMBL2205767 Bioactive
5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(2,2,2-trifluoroethyl)pyridine-3-sulfonamide CFAMM00404195 CHEMBL2059913 Bioactive
1-[6-[5-(tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-(2-morpholin-4-ylethyl)urea CFAMM00404207 CHEMBL2064571 Bioactive
CZC24832 CFAMM00404187 CHEMBL2205763 Bioactive
5-(2-amino-5-fluoro-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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