CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10754
Family Name Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-[(2S)-2-[[(2S)-2-benzyl-3-sulfanylpropanoyl]amino]propanoyl]-2,3-dihydroindole-2-carboxylic acid family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00404212 Functional Category Bioactive
Superfamily Angiotensin-converting enzyme and Neprilysin Binder Superfamily
Class Class 3583

Cousin Family NamesSeedsMembers
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Cyclophilin receptor and Cyclosporine receptor Ligand D-43787 ... 2 13
Neprilysin Inhibitor Thiorphan Family 41 68
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 18
Integrin beta-3 Inhibitor L-750034 Family 7 38
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Protein kinase C eta type and Protein kinase C delta type Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-(n-phenylamino)pheny... 2 3
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 5
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
D(4) dopamine receptor and D(2) dopamine receptor ligand methy... 2 11
Angiotensin-converting enzyme inhibitor AGN-PC-074KD3 family 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Angiotensin-converting enzyme inhibitor (2R)-1-[4-carboxy-4-(p... 3 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Angiotensin-converting enzyme inhibitor (2S)-1-[(2S)-2-sulfany... 7 23
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN1499864 family 4 7
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Angiotensin-converting enzyme inhibitor (2S,4S,5R)-1-[(2R)-2-a... 1 1
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
Angiotensin-converting enzyme inhibitor 1-[(2R,4R)-4-carboxy-2... 2 3
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
fMet-Leu-Phe receptor ligand (2S)-2-[[(2S)-2-[[(2S)-2-[(4-chlo... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Angiotensin-converting enzyme inhibitor 2-(N-[(2S)-6-amino-2-[... 2 1
Granzyme B and Caspase-3 inhibitor CHEMBL304368 family 2 1
Caspase-8 and Caspase-3 inhibitor (3S)-3-[[(2S)-4-methyl-2-[[2... 3 2
Angiotensin-converting enzyme inhibitor 89177-63-9 family 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-[2-[... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-009EMK... 2 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 0
Nitric oxide synthase, endothelial and Nitric oxide synthase, ... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00404212 CHEMBL50582 Bioactive (2S)-1-[(2S)-2-[[(2S)-2-benzyl-3-sulfanylpropanoyl]amino]propanoyl]-2,3-dihydroindole-2-carboxylic acid
CFAMM00404208 CHEMBL89840 Bioactive (2S,5R)-1-[2-[[(2S)-3-(4-aminophenyl)-2-sulfanylpropanoyl]amino]acetyl]-5-phenylpyrrolidine-2-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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